FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983757435> ?p ?o ?g. }

• W1983757435 endingPage "240" @default.
• W1983757435 startingPage "235" @default.
• W1983757435 abstract "The treatment of HBeAg-negative chronic hepatitis B with alpha interferon alone is unsatisfactory. We evaluated the efficacy of combined administration of interferon-a2a (IFN) with oral ganciclovir, a nucleoside analogue. Forty patients with hepatitis B virus (HBV)-DNA-positive/HBeAg-negative chronic hepatitis B, were randomized to receive 4.5 MU IFN thrice weekly, subcutaneously, alone or in combination with 3 g ganciclovir per os daily for 26 weeks and followed for 12 months after treatment. Mean serum HBV-DNA levels decreased by 4.0 log10 in the combination group (from 5 x 106 to 4.8 x 102 copies/ml) and by 2.2 log10 in the interferon group (from 8 x 106 to 4.8 x 104 copies/ml) by quantitative polymerase chain reaction (PCR). HBV-DNA became undetectable in 11 of 20 (55%) and in three of 20 (15%) patients in the two groups, respectively (P=0.02). The alanine aminotransferase levels became normal in all patients receiving combination therapy, compared to 75% of those in the interferon group. After cessation of therapy, HBV-DNA increased or reappeared in all patients with 85% also relapsing biochemically. One year after treatment, three patients in each group (15%) remained in sustained biochemical remission with very low serum HBV-DNA levels (median 15 700 copies/ml). We conclude that, in HBeAg-negative chronic hepatitis B, 6-month combination therapy with oral ganciclovir and IFN is associated with complete biochemical remission in all treated patients and a 4 log10 decrease in serum HBV-DNA levels. The end of treatment efficacy of this combination scheme is far super- ior to that of IFN monotherapy but sustained responses are few. Further studies are warranted to evaluate the efficacy of prolonged combination schemes with nucleoside analogues and IFN, compared to IFN monotherapy." @default.
• W1983757435 created "2016-06-24" @default.
• W1983757435 creator A5015786317 @default.
• W1983757435 creator A5064949118 @default.
• W1983757435 creator A5072590318 @default.
• W1983757435 creator A5082142758 @default.
• W1983757435 creator A5091246846 @default.
• W1983757435 date "2000-05-01" @default.
• W1983757435 modified "2023-09-27" @default.
• W1983757435 title "Interferon treatment with or without oral ganciclovir in HBeAg-negative chronic hepatitis B: a randomized study" @default.
• W1983757435 cites W1594706749 @default.
• W1983757435 cites W1978724373 @default.
• W1983757435 cites W1981900811 @default.
• W1983757435 cites W1991592276 @default.
• W1983757435 cites W1995079446 @default.
• W1983757435 cites W1996859721 @default.
• W1983757435 cites W2007423548 @default.
• W1983757435 cites W2028918128 @default.
• W1983757435 cites W2030161442 @default.
• W1983757435 cites W2038358235 @default.
• W1983757435 cites W2041104891 @default.
• W1983757435 cites W2041473358 @default.
• W1983757435 cites W2085872870 @default.
• W1983757435 cites W2085990351 @default.
• W1983757435 cites W2090041613 @default.
• W1983757435 cites W2103368601 @default.
• W1983757435 cites W2122863469 @default.
• W1983757435 cites W2164327796 @default.
• W1983757435 cites W2170268409 @default.
• W1983757435 cites W2293495463 @default.
• W1983757435 cites W2323719395 @default.
• W1983757435 cites W2338794667 @default.
• W1983757435 doi "https://doi.org/10.1046/j.1365-2893.2000.00220.x" @default.
• W1983757435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10849267" @default.
• W1983757435 hasPublicationYear "2000" @default.
• W1983757435 type Work @default.
• W1983757435 sameAs 1983757435 @default.
• W1983757435 citedByCount "12" @default.
• W1983757435 crossrefType "journal-article" @default.
• W1983757435 hasAuthorship W1983757435A5015786317 @default.
• W1983757435 hasAuthorship W1983757435A5064949118 @default.
• W1983757435 hasAuthorship W1983757435A5072590318 @default.
• W1983757435 hasAuthorship W1983757435A5082142758 @default.
• W1983757435 hasAuthorship W1983757435A5091246846 @default.
• W1983757435 hasConcept C126322002 @default.
• W1983757435 hasConcept C159047783 @default.
• W1983757435 hasConcept C203014093 @default.
• W1983757435 hasConcept C2522874641 @default.
• W1983757435 hasConcept C2775940106 @default.
• W1983757435 hasConcept C2776178377 @default.
• W1983757435 hasConcept C2776543447 @default.
• W1983757435 hasConcept C2776999253 @default.
• W1983757435 hasConcept C2777333352 @default.
• W1983757435 hasConcept C2777382497 @default.
• W1983757435 hasConcept C2777410769 @default.
• W1983757435 hasConcept C2777965375 @default.
• W1983757435 hasConcept C2779820661 @default.
• W1983757435 hasConcept C2780593183 @default.
• W1983757435 hasConcept C2909179924 @default.
• W1983757435 hasConcept C3020491458 @default.
• W1983757435 hasConcept C55493867 @default.
• W1983757435 hasConcept C71924100 @default.
• W1983757435 hasConcept C86803240 @default.
• W1983757435 hasConcept C90924648 @default.
• W1983757435 hasConceptScore W1983757435C126322002 @default.
• W1983757435 hasConceptScore W1983757435C159047783 @default.
• W1983757435 hasConceptScore W1983757435C203014093 @default.
• W1983757435 hasConceptScore W1983757435C2522874641 @default.
• W1983757435 hasConceptScore W1983757435C2775940106 @default.
• W1983757435 hasConceptScore W1983757435C2776178377 @default.
• W1983757435 hasConceptScore W1983757435C2776543447 @default.
• W1983757435 hasConceptScore W1983757435C2776999253 @default.
• W1983757435 hasConceptScore W1983757435C2777333352 @default.
• W1983757435 hasConceptScore W1983757435C2777382497 @default.
• W1983757435 hasConceptScore W1983757435C2777410769 @default.
• W1983757435 hasConceptScore W1983757435C2777965375 @default.
• W1983757435 hasConceptScore W1983757435C2779820661 @default.
• W1983757435 hasConceptScore W1983757435C2780593183 @default.
• W1983757435 hasConceptScore W1983757435C2909179924 @default.
• W1983757435 hasConceptScore W1983757435C3020491458 @default.
• W1983757435 hasConceptScore W1983757435C55493867 @default.
• W1983757435 hasConceptScore W1983757435C71924100 @default.
• W1983757435 hasConceptScore W1983757435C86803240 @default.
• W1983757435 hasConceptScore W1983757435C90924648 @default.
• W1983757435 hasIssue "3" @default.
• W1983757435 hasLocation W19837574351 @default.
• W1983757435 hasLocation W19837574352 @default.
• W1983757435 hasOpenAccess W1983757435 @default.
• W1983757435 hasPrimaryLocation W19837574351 @default.
• W1983757435 hasRelatedWork W1984841243 @default.
• W1983757435 hasRelatedWork W1992194872 @default.
• W1983757435 hasRelatedWork W1994072262 @default.
• W1983757435 hasRelatedWork W2052968140 @default.
• W1983757435 hasRelatedWork W2077300867 @default.
• W1983757435 hasRelatedWork W2084720260 @default.
• W1983757435 hasRelatedWork W2097375253 @default.
• W1983757435 hasRelatedWork W2100091582 @default.
• W1983757435 hasRelatedWork W2187341310 @default.

• next