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• W1983759743 endingPage "1462" @default.
• W1983759743 startingPage "1448" @default.
• W1983759743 abstract "Formation of mesoderm in Xenopus embryos is the result of an induction event in which peptides such as FGF or activins have been implicated. It was recently demonstrated, by the ectopic expression of a truncated activin receptor, that activin receptor signaling pathways are involved in the processes of mesoderm and axis formation in vivo. However, this approach does not directly address the role of activin itself nor the involvement of activins in the formation of mesoderm in embryos from other vertebrates. In addition, activins are expressed maternally as a protein component of the egg as well as transcribed zygotically, and it is not clear which of the two forms is involved in mesoderm formation. To address those three issues, we analyzed the role of activins in the development of fish embryos by generating two activin dominant-negative variants. One of the variants behaves as an inhibitor of activin protein. The second variant was found to deplete the activin pool when cotranslated with wild-type activin. Injection of RNA encoding these variants into the two-cell embryo of the small teleost fish Oryzias latipes (Japanese medaka) demonstrates that only the maternally provided activin protein is required for mesoderm and axis formation in fish in vivo." @default.
• W1983759743 created "2016-06-24" @default.
• W1983759743 creator A5027273946 @default.
• W1983759743 creator A5072696982 @default.
• W1983759743 date "1994-06-15" @default.
• W1983759743 modified "2023-10-17" @default.
• W1983759743 title "Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin." @default.
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• W1983759743 doi "https://doi.org/10.1101/gad.8.12.1448" @default.
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