Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983764912> ?p ?o ?g. }
- W1983764912 endingPage "518" @default.
- W1983764912 startingPage "511" @default.
- W1983764912 abstract "Abstract Extracellular ATP (eATP), the most abundant among nucleotides, can act as a mediator during inflammatory responses by binding to plasmamembrane P2 purinergic receptors, which are widely expressed on cells of the immune system. eATP is generally considered as a classical danger signal, which stimulates immune responses in the presence of tissue damage. Converging evidence from several studies using murine models of chronic inflammation have supported this hypothesis; however, the role of eATP in the regulation of human immune function appears to be more complex. Chronic stimulation with micromolar eATP concentrations inhibits the proliferation of T and NK lymphocytes and enhances the capacity of dendritic cells to promote tolerance. The effect of eATP depends on multiple factors, such as the extent of stimulation, eATP concentration, presence/absence of other mediators in the microenvironment, and pattern of P2 receptor engagement. Small but significant differences in the pattern of P2 receptor expression in mice and humans confer the diverse capacities of ATP in regulating the immune response. Such diversity, which is often overlooked, should therefore be carefully considered when evaluating the role of eATP in human inflammatory and autoimmune diseases." @default.
- W1983764912 created "2016-06-24" @default.
- W1983764912 creator A5004877803 @default.
- W1983764912 creator A5018511375 @default.
- W1983764912 creator A5035684147 @default.
- W1983764912 creator A5081364563 @default.
- W1983764912 date "2012-07-19" @default.
- W1983764912 modified "2023-09-29" @default.
- W1983764912 title "Immunoregulation through extracellular nucleotides" @default.
- W1983764912 cites W1485797978 @default.
- W1983764912 cites W1494175510 @default.
- W1983764912 cites W1495057561 @default.
- W1983764912 cites W1510165700 @default.
- W1983764912 cites W1532386517 @default.
- W1983764912 cites W1585686035 @default.
- W1983764912 cites W1602068304 @default.
- W1983764912 cites W1680796204 @default.
- W1983764912 cites W1755638404 @default.
- W1983764912 cites W1877412971 @default.
- W1983764912 cites W1880785174 @default.
- W1983764912 cites W1906612937 @default.
- W1983764912 cites W1910149072 @default.
- W1983764912 cites W1947888345 @default.
- W1983764912 cites W1949136531 @default.
- W1983764912 cites W1964663565 @default.
- W1983764912 cites W1965130745 @default.
- W1983764912 cites W1967663682 @default.
- W1983764912 cites W1971084572 @default.
- W1983764912 cites W1972657056 @default.
- W1983764912 cites W1975035330 @default.
- W1983764912 cites W1977117027 @default.
- W1983764912 cites W1978274182 @default.
- W1983764912 cites W1980927246 @default.
- W1983764912 cites W1982230576 @default.
- W1983764912 cites W1983009411 @default.
- W1983764912 cites W1987062630 @default.
- W1983764912 cites W1987518018 @default.
- W1983764912 cites W1989545734 @default.
- W1983764912 cites W1990809029 @default.
- W1983764912 cites W1994704158 @default.
- W1983764912 cites W1995810932 @default.
- W1983764912 cites W1996811758 @default.
- W1983764912 cites W2000625547 @default.
- W1983764912 cites W2011060501 @default.
- W1983764912 cites W2014461458 @default.
- W1983764912 cites W2018585106 @default.
- W1983764912 cites W2018612932 @default.
- W1983764912 cites W2019702139 @default.
- W1983764912 cites W2024250469 @default.
- W1983764912 cites W2029022613 @default.
- W1983764912 cites W2029100084 @default.
- W1983764912 cites W2029123674 @default.
- W1983764912 cites W2034321048 @default.
- W1983764912 cites W2034442219 @default.
- W1983764912 cites W2034643457 @default.
- W1983764912 cites W2038602542 @default.
- W1983764912 cites W2042906495 @default.
- W1983764912 cites W2044937310 @default.
- W1983764912 cites W2051529467 @default.
- W1983764912 cites W2052556658 @default.
- W1983764912 cites W2053763669 @default.
- W1983764912 cites W2063557216 @default.
- W1983764912 cites W2065009203 @default.
- W1983764912 cites W2069058630 @default.
- W1983764912 cites W2081501101 @default.
- W1983764912 cites W2082548175 @default.
- W1983764912 cites W2083566457 @default.
- W1983764912 cites W2085698560 @default.
- W1983764912 cites W2092749162 @default.
- W1983764912 cites W2094133105 @default.
- W1983764912 cites W2096539359 @default.
- W1983764912 cites W2096663326 @default.
- W1983764912 cites W2100452437 @default.
- W1983764912 cites W2104082830 @default.
- W1983764912 cites W2104414795 @default.
- W1983764912 cites W2106190040 @default.
- W1983764912 cites W2108589013 @default.
- W1983764912 cites W2111178472 @default.
- W1983764912 cites W2116867036 @default.
- W1983764912 cites W2119228184 @default.
- W1983764912 cites W2122631210 @default.
- W1983764912 cites W2127254182 @default.
- W1983764912 cites W2129388928 @default.
- W1983764912 cites W2132958789 @default.
- W1983764912 cites W2137141750 @default.
- W1983764912 cites W2138985573 @default.
- W1983764912 cites W2144373920 @default.
- W1983764912 cites W2145911009 @default.
- W1983764912 cites W2148053686 @default.
- W1983764912 cites W2156346381 @default.
- W1983764912 cites W2156722597 @default.
- W1983764912 cites W2157724221 @default.
- W1983764912 cites W2159669268 @default.
- W1983764912 cites W2164116575 @default.
- W1983764912 cites W2168535576 @default.
- W1983764912 cites W2180780341 @default.
- W1983764912 cites W2324235425 @default.
- W1983764912 cites W299010878 @default.