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- W1983764955 abstract "Host cell invasion by apicomplexan parasites requires coordinated interactions between cell surface adhesins and the parasite cytoskeleton. We have identified a complex of parasite proteins, including the actin binding protein aldolase, which specifically interacts with the C-terminal domains of several parasite adhesins belonging to the thrombospondin-related anonymous protein (TRAP) family. Binding of aldolase to the adhesin was disrupted by mutation of a critical tryptophan in the C domain, a residue that was previously shown to be essential for parasite motility. Our findings reveal a potential role for aldolase in connecting TRAP family adhesins with the cytoskeleton, and provide a model linking adhesion with motility in apicomplexan parasites." @default.
- W1983764955 created "2016-06-24" @default.
- W1983764955 creator A5046052844 @default.
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- W1983764955 date "2003-04-01" @default.
- W1983764955 modified "2023-10-02" @default.
- W1983764955 title "Aldolase Forms a Bridge between Cell Surface Adhesins and the Actin Cytoskeleton in Apicomplexan Parasites" @default.
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- W1983764955 doi "https://doi.org/10.1016/s1097-2765(03)00113-8" @default.
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