FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983769268> ?p ?o ?g. }

• W1983769268 endingPage "905" @default.
• W1983769268 startingPage "893" @default.
• W1983769268 abstract "Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anticancer agents designed to infect and lyse tumor cells. However, in spite of their promise as selective cancer therapeutics, replicating adenoviruses have shown limited efficacy in the clinical setting. We hypothesized that a CRAd armed with osteoprotegerin (OPG) would eradicate bone metastases of breast cancer both directly, by oncolysis, and indirectly, by inhibiting osteoclastic bone resorption, and thus reducing the tumor burden. We constructed an armed CRAd (Ad5-Δ24-sOPG-Fc-RGD) by replacing viral E3B genes with a fusion of the ligand-binding domains of OPG and the Fc portion of human IgG1. Conditional replication was conferred by a 24-base pair deletion within E1A (Δ24), which prevents the binding of E1A to the retinoblastoma tumor suppressor/cell cycle regulator protein and limits replication in normal cells. Enhanced infection of cells expressing low levels of the primary Ad5 receptor was conferred by incorporating an arginine-glycine-aspartic acid (RGD) peptide sequence into the fiber knob to mediate binding to αv integrins. After characterization of the armed CRAd, we demonstrated that infection of breast cancer cells by Ad5-Δ24-sOPG-Fc-RGD both killed the infected cells by oncolysis and inhibited the formation of osteoclasts in an in vitro co-culture model. In a murine model of osteolytic bone metastases of breast cancer, the CRAd armed with shortened OPG (sOPG)-Fc reduced tumor burden in the bone and inhibited osteoclast formation more effectively than an unarmed CRAd." @default.
• W1983769268 created "2016-06-24" @default.
• W1983769268 creator A5012954910 @default.
• W1983769268 creator A5013064348 @default.
• W1983769268 creator A5016393533 @default.
• W1983769268 creator A5017208495 @default.
• W1983769268 creator A5017218508 @default.
• W1983769268 creator A5024420238 @default.
• W1983769268 creator A5026981314 @default.
• W1983769268 creator A5036232956 @default.
• W1983769268 creator A5036647389 @default.
• W1983769268 creator A5042575274 @default.
• W1983769268 creator A5049106949 @default.
• W1983769268 creator A5053667246 @default.
• W1983769268 creator A5075830709 @default.
• W1983769268 date "2010-08-27" @default.
• W1983769268 modified "2023-10-11" @default.
• W1983769268 title "Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer" @default.
• W1983769268 cites W1491631791 @default.
• W1983769268 cites W1544229812 @default.
• W1983769268 cites W1572693845 @default.
• W1983769268 cites W1984986252 @default.
• W1983769268 cites W1985727076 @default.
• W1983769268 cites W1986310612 @default.
• W1983769268 cites W1987254959 @default.
• W1983769268 cites W1989526399 @default.
• W1983769268 cites W2000647744 @default.
• W1983769268 cites W2011942975 @default.
• W1983769268 cites W2012672965 @default.
• W1983769268 cites W2012714016 @default.
• W1983769268 cites W2018602999 @default.
• W1983769268 cites W2021505980 @default.
• W1983769268 cites W2021951737 @default.
• W1983769268 cites W2041243019 @default.
• W1983769268 cites W2041327218 @default.
• W1983769268 cites W2043651158 @default.
• W1983769268 cites W2046035469 @default.
• W1983769268 cites W2063699543 @default.
• W1983769268 cites W2071026717 @default.
• W1983769268 cites W2078549990 @default.
• W1983769268 cites W2079523736 @default.
• W1983769268 cites W2086008590 @default.
• W1983769268 cites W2086491566 @default.
• W1983769268 cites W2087324367 @default.
• W1983769268 cites W2087378917 @default.
• W1983769268 cites W2089145565 @default.
• W1983769268 cites W2096884368 @default.
• W1983769268 cites W2098264302 @default.
• W1983769268 cites W2103596289 @default.
• W1983769268 cites W2110592777 @default.
• W1983769268 cites W2111807012 @default.
• W1983769268 cites W2112523271 @default.
• W1983769268 cites W2117963070 @default.
• W1983769268 cites W2119263434 @default.
• W1983769268 cites W2136257629 @default.
• W1983769268 cites W2145238190 @default.
• W1983769268 cites W2146465225 @default.
• W1983769268 cites W2147961945 @default.
• W1983769268 cites W2148712735 @default.
• W1983769268 cites W2156031288 @default.
• W1983769268 cites W2163010298 @default.
• W1983769268 cites W2313228602 @default.
• W1983769268 cites W2330302356 @default.
• W1983769268 cites W4230836190 @default.
• W1983769268 cites W4237815080 @default.
• W1983769268 doi "https://doi.org/10.1038/cgt.2010.47" @default.
• W1983769268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842170" @default.
• W1983769268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20798695" @default.
• W1983769268 hasPublicationYear "2010" @default.
• W1983769268 type Work @default.
• W1983769268 sameAs 1983769268 @default.
• W1983769268 citedByCount "18" @default.
• W1983769268 countsByYear W19837692682012 @default.
• W1983769268 countsByYear W19837692682013 @default.
• W1983769268 countsByYear W19837692682015 @default.
• W1983769268 countsByYear W19837692682016 @default.
• W1983769268 countsByYear W19837692682017 @default.
• W1983769268 countsByYear W19837692682018 @default.
• W1983769268 countsByYear W19837692682019 @default.
• W1983769268 countsByYear W19837692682021 @default.
• W1983769268 crossrefType "journal-article" @default.
• W1983769268 hasAuthorship W1983769268A5012954910 @default.
• W1983769268 hasAuthorship W1983769268A5013064348 @default.
• W1983769268 hasAuthorship W1983769268A5016393533 @default.
• W1983769268 hasAuthorship W1983769268A5017208495 @default.
• W1983769268 hasAuthorship W1983769268A5017218508 @default.
• W1983769268 hasAuthorship W1983769268A5024420238 @default.
• W1983769268 hasAuthorship W1983769268A5026981314 @default.
• W1983769268 hasAuthorship W1983769268A5036232956 @default.
• W1983769268 hasAuthorship W1983769268A5036647389 @default.
• W1983769268 hasAuthorship W1983769268A5042575274 @default.
• W1983769268 hasAuthorship W1983769268A5049106949 @default.
• W1983769268 hasAuthorship W1983769268A5053667246 @default.
• W1983769268 hasAuthorship W1983769268A5075830709 @default.
• W1983769268 hasBestOaLocation W19837692681 @default.
• W1983769268 hasConcept C104317684 @default.
• W1983769268 hasConcept C111599444 @default.
• W1983769268 hasConcept C121608353 @default.

• next