FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983770110> ?p ?o ?g. }

• W1983770110 endingPage "440" @default.
• W1983770110 startingPage "433" @default.
• W1983770110 abstract "OBJECTIVES: The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these drugs in this situation is limited. Our aim is to assess the safety of thiopurines and anti-TNF-α drugs for the treatment of inflammatory bowel disease (IBD) during pregnancy. METHODS: Retrospective, multicenter study in IBD patients. Pregnancies were classified according to the therapeutic regimens during pregnancy or during the 3 months before the conception: non-exposed group, pregnancies exposed to thiopurines alone (group A), and pregnancies exposed to anti-TNF-α drugs (group B). An unfavorableGlobal Pregnancy Outcome(GPO) was considered if pregnancy developed with obstetric complications in the mother and in the newborn. RESULTS: A total of 187 pregnancies in the group A, 66 pregnancies in the group B, and 318 pregnancies in thenon-exposedgroup were included. The rate of unfavorableGPOwas different among the three groups (31.8% innon-exposedgroup, 21.9% in group A, and 34.8% in group B), being lower in pregnancies under thiopurines than amongnon-exposed(P=0.01). The rate of pregnancy complications was similar among the three groups (27.7% innon-exposed, 20.9% in group A, and 30.3% in group B). The rate of neonatal complications was different among the three groups (23.3% innon-exposedgroup, 13.9% in group A, and 21.2% in group B), being lower in pregnancies under thiopurines than amongnon-exposed(P=0.01). In the multivariate analysis, the treatment with thiopurines (odds ratio=0.6; 95% confidence interval=0.4–0.9,P=0.02) was the only predictor of favorableGPO, whereas maternal age >35 years at conception was the only predictor of unfavorableGPO. The treatment with anti-TNF-α drugs was not associated with an unfavorableGPO. CONCLUSION: The treatment with thiopurines and anti-TNF-α drugs does not seem to increase the risk of complications during pregnancy and does seem to be safe for the newborn." @default.
• W1983770110 created "2016-06-24" @default.
• W1983770110 creator A5005448698 @default.
• W1983770110 creator A5009437472 @default.
• W1983770110 creator A5009906875 @default.
• W1983770110 creator A5010636425 @default.
• W1983770110 creator A5011224876 @default.
• W1983770110 creator A5013169894 @default.
• W1983770110 creator A5013238742 @default.
• W1983770110 creator A5013957241 @default.
• W1983770110 creator A5014918083 @default.
• W1983770110 creator A5017645171 @default.
• W1983770110 creator A5019026198 @default.
• W1983770110 creator A5020958920 @default.
• W1983770110 creator A5029279273 @default.
• W1983770110 creator A5031350614 @default.
• W1983770110 creator A5032022974 @default.
• W1983770110 creator A5034116654 @default.
• W1983770110 creator A5037356434 @default.
• W1983770110 creator A5038265124 @default.
• W1983770110 creator A5040944358 @default.
• W1983770110 creator A5044749003 @default.
• W1983770110 creator A5045306064 @default.
• W1983770110 creator A5053129179 @default.
• W1983770110 creator A5064167457 @default.
• W1983770110 creator A5067172585 @default.
• W1983770110 creator A5074256103 @default.
• W1983770110 creator A5074679114 @default.
• W1983770110 creator A5079272254 @default.
• W1983770110 creator A5081766332 @default.
• W1983770110 creator A5084337079 @default.
• W1983770110 date "2013-03-01" @default.
• W1983770110 modified "2023-10-18" @default.
• W1983770110 title "Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease" @default.
• W1983770110 cites W1552181711 @default.
• W1983770110 cites W1558923886 @default.
• W1983770110 cites W1963901180 @default.
• W1983770110 cites W1966646921 @default.
• W1983770110 cites W1969072712 @default.
• W1983770110 cites W1969412874 @default.
• W1983770110 cites W1969469563 @default.
• W1983770110 cites W1972147294 @default.
• W1983770110 cites W1979456617 @default.
• W1983770110 cites W1988000889 @default.
• W1983770110 cites W2001598534 @default.
• W1983770110 cites W2003785835 @default.
• W1983770110 cites W2006713077 @default.
• W1983770110 cites W2015723312 @default.
• W1983770110 cites W2018313341 @default.
• W1983770110 cites W2025464773 @default.
• W1983770110 cites W2029476001 @default.
• W1983770110 cites W2030173580 @default.
• W1983770110 cites W2031860350 @default.
• W1983770110 cites W2034303304 @default.
• W1983770110 cites W2034848575 @default.
• W1983770110 cites W203735430 @default.
• W1983770110 cites W2047212658 @default.
• W1983770110 cites W2055734184 @default.
• W1983770110 cites W2058060946 @default.
• W1983770110 cites W2058382083 @default.
• W1983770110 cites W2064447790 @default.
• W1983770110 cites W2080428749 @default.
• W1983770110 cites W2080814854 @default.
• W1983770110 cites W2094902829 @default.
• W1983770110 cites W2101604689 @default.
• W1983770110 cites W2102087425 @default.
• W1983770110 cites W2107714591 @default.
• W1983770110 cites W2110661132 @default.
• W1983770110 cites W2117613260 @default.
• W1983770110 cites W2121146612 @default.
• W1983770110 cites W2122763081 @default.
• W1983770110 cites W2123799332 @default.
• W1983770110 cites W2139877652 @default.
• W1983770110 cites W2140399841 @default.
• W1983770110 cites W2144550346 @default.
• W1983770110 cites W2148609867 @default.
• W1983770110 cites W2156275748 @default.
• W1983770110 cites W2159505776 @default.
• W1983770110 cites W2163556442 @default.
• W1983770110 cites W4240052209 @default.
• W1983770110 doi "https://doi.org/10.1038/ajg.2012.430" @default.
• W1983770110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23318480" @default.
• W1983770110 hasPublicationYear "2013" @default.
• W1983770110 type Work @default.
• W1983770110 sameAs 1983770110 @default.
• W1983770110 citedByCount "198" @default.
• W1983770110 countsByYear W19837701102013 @default.
• W1983770110 countsByYear W19837701102014 @default.
• W1983770110 countsByYear W19837701102015 @default.
• W1983770110 countsByYear W19837701102016 @default.
• W1983770110 countsByYear W19837701102017 @default.
• W1983770110 countsByYear W19837701102018 @default.
• W1983770110 countsByYear W19837701102019 @default.
• W1983770110 countsByYear W19837701102020 @default.
• W1983770110 countsByYear W19837701102021 @default.
• W1983770110 countsByYear W19837701102022 @default.
• W1983770110 countsByYear W19837701102023 @default.
• W1983770110 crossrefType "journal-article" @default.

• next