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• W1983792336 abstract "Endogenous glucocorticoids (GC) can be metabolized through the enzyme 11β-hydroxysteroid dehydrogenase (11β-OHSD); in the rat, corticosterone (B) is converted to its inactive metabolite 11-dehydrocorticosterone (A). Since increased tissue concentrations of GCs may affect blood pressure by potentiating the vasoactive effects of α-adrenergic agonists and possibly other pressors, we studied the metabolism of corticosterone in freshly dissected aortae and cultured vascular smooth muscle cells (VSMC). Incubations were generally conducted for 60 min with 10−8 M steroid; steroids were isolated and identified by HPLC. In aortic minces stripped of endothelium, the oxo-reductase reaction of A back to B was nearly 4 times greater than the dehydrogenase reaction of B to A (2.8 ± 0.5 × 10−11 versus 7.3 ± 1.0 × 10−12 mol/mg protein). This pattern was also seen in cultured VSMC during growth and quiescent states (growth A to B 3.2 ± 0.4 × 10−12 versus B to A 9.7 ± 0.9 × 10−13 mol/mg protein; quiescent A to B 8.8 ± 0.1 × 10−12 versus B to A 1.2 ± 0.2 × 10−12 mol/mg protein). Enzyme activity in either direction was less during growth, correlating with a decrease in mRNA for 11β-OHSD. In cell homogenates containing 200 μM NADP(H), the enzyme functioned equally in either direction at pH 7.4 with an apparent Km for corticosterone of approximately 2 × 10−7 M. Carbenoxolone, an inhibitor of 11β-OHSD, suppressed the dehydrogenase reaction to a greater degree than the reverse oxo-reductase reaction. Thus, in VSMC 11β-OHSD is bidirectional; under physiologic conditions intact VSMC favor the oxo-reductase reaction. Quiescent cells show greater enzyme activity than actively growing cells." @default.
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• W1983792336 date "1995-05-01" @default.
• W1983792336 modified "2023-09-23" @default.
• W1983792336 title "Bidirectional activity of 11β-hydroxysteroid dehydrogenase in vascular smooth muscle cells" @default.
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• W1983792336 doi "https://doi.org/10.1016/0039-128x(94)00074-m" @default.
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