FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983800116> ?p ?o ?g. }

• W1983800116 endingPage "180" @default.
• W1983800116 startingPage "175" @default.
• W1983800116 abstract "Blonanserin is a novel antipsychotic agent that preferentially interacts with dopamine D2 and 5-HT2A receptors. To assess the atypical properties of blonanserin, we evaluated its propensity to induce extrapyramidal side effects (EPS) and to enhance forebrain Fos expression in mice. The actions of AD-6048, a primary metabolite of blonanserin, in modulating haloperidol-induced EPS were also examined. Blonanserin (0.3–10 mg/kg, p.o.) did not significantly alter the pole-descending behavior of mice in the pole test or increase the catalepsy time, while haloperidol (0.3–3 mg/kg, p.o.) caused pronounced bradykinesia and catalepsy. Blonanserin and haloperidol at the above doses significantly enhanced Fos expression in the shell (AcS) region of the nucleus accumbens and dorsolateral striatum (dlST). The extent of blonanserin-induced Fos expression in the AcS was comparable to that induced by haloperidol. However, the striatal Fos expression by blonanserin was less prominent as compared to haloperidol. Furthermore, combined treatment of AD-6048 (0.1–3 mg/kg, s.c.) with haloperidol (0.5 mg/kg, i.p.) significantly attenuated haloperidol-induced bradykinesia and catalepsy. The present results show that blonanserin behaves as an atypical antipsychotic both in inducing EPS and enhancing forebrain Fos expression. In addition, AD-6048 seems to contribute at least partly to the atypical properties of blonanserin." @default.
• W1983800116 created "2016-06-24" @default.
• W1983800116 creator A5000642935 @default.
• W1983800116 creator A5011403233 @default.
• W1983800116 creator A5013647008 @default.
• W1983800116 creator A5050238592 @default.
• W1983800116 creator A5070157804 @default.
• W1983800116 creator A5075189857 @default.
• W1983800116 date "2010-08-01" @default.
• W1983800116 modified "2023-09-26" @default.
• W1983800116 title "Atypical antipsychotic properties of blonanserin, a novel dopamine D2 and 5-HT2A antagonist" @default.
• W1983800116 cites W162017141 @default.
• W1983800116 cites W1972693484 @default.
• W1983800116 cites W1975837516 @default.
• W1983800116 cites W1986105781 @default.
• W1983800116 cites W1986645031 @default.
• W1983800116 cites W1987547042 @default.
• W1983800116 cites W1996026492 @default.
• W1983800116 cites W2003299840 @default.
• W1983800116 cites W2003564452 @default.
• W1983800116 cites W2015211750 @default.
• W1983800116 cites W2024300142 @default.
• W1983800116 cites W2033490388 @default.
• W1983800116 cites W2056825115 @default.
• W1983800116 cites W2061560549 @default.
• W1983800116 cites W2062610641 @default.
• W1983800116 cites W2081432988 @default.
• W1983800116 cites W2081569033 @default.
• W1983800116 cites W2083228450 @default.
• W1983800116 cites W2083348702 @default.
• W1983800116 cites W2095213614 @default.
• W1983800116 cites W2098903596 @default.
• W1983800116 cites W2118527319 @default.
• W1983800116 cites W2161026345 @default.
• W1983800116 cites W2401206973 @default.
• W1983800116 cites W4229844282 @default.
• W1983800116 doi "https://doi.org/10.1016/j.pbb.2010.04.027" @default.
• W1983800116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20460137" @default.
• W1983800116 hasPublicationYear "2010" @default.
• W1983800116 type Work @default.
• W1983800116 sameAs 1983800116 @default.
• W1983800116 citedByCount "27" @default.
• W1983800116 countsByYear W19838001162012 @default.
• W1983800116 countsByYear W19838001162013 @default.
• W1983800116 countsByYear W19838001162014 @default.
• W1983800116 countsByYear W19838001162015 @default.
• W1983800116 countsByYear W19838001162016 @default.
• W1983800116 countsByYear W19838001162019 @default.
• W1983800116 countsByYear W19838001162020 @default.
• W1983800116 countsByYear W19838001162021 @default.
• W1983800116 countsByYear W19838001162022 @default.
• W1983800116 crossrefType "journal-article" @default.
• W1983800116 hasAuthorship W1983800116A5000642935 @default.
• W1983800116 hasAuthorship W1983800116A5011403233 @default.
• W1983800116 hasAuthorship W1983800116A5013647008 @default.
• W1983800116 hasAuthorship W1983800116A5050238592 @default.
• W1983800116 hasAuthorship W1983800116A5070157804 @default.
• W1983800116 hasAuthorship W1983800116A5075189857 @default.
• W1983800116 hasConcept C118552586 @default.
• W1983800116 hasConcept C134018914 @default.
• W1983800116 hasConcept C15744967 @default.
• W1983800116 hasConcept C170493617 @default.
• W1983800116 hasConcept C185592680 @default.
• W1983800116 hasConcept C2776412080 @default.
• W1983800116 hasConcept C2776552330 @default.
• W1983800116 hasConcept C2776885963 @default.
• W1983800116 hasConcept C2779715522 @default.
• W1983800116 hasConcept C2780062018 @default.
• W1983800116 hasConcept C2780476085 @default.
• W1983800116 hasConcept C2780494398 @default.
• W1983800116 hasConcept C2780948584 @default.
• W1983800116 hasConcept C44208683 @default.
• W1983800116 hasConcept C513476851 @default.
• W1983800116 hasConcept C529278444 @default.
• W1983800116 hasConcept C55493867 @default.
• W1983800116 hasConcept C71924100 @default.
• W1983800116 hasConcept C98274493 @default.
• W1983800116 hasConceptScore W1983800116C118552586 @default.
• W1983800116 hasConceptScore W1983800116C134018914 @default.
• W1983800116 hasConceptScore W1983800116C15744967 @default.
• W1983800116 hasConceptScore W1983800116C170493617 @default.
• W1983800116 hasConceptScore W1983800116C185592680 @default.
• W1983800116 hasConceptScore W1983800116C2776412080 @default.
• W1983800116 hasConceptScore W1983800116C2776552330 @default.
• W1983800116 hasConceptScore W1983800116C2776885963 @default.
• W1983800116 hasConceptScore W1983800116C2779715522 @default.
• W1983800116 hasConceptScore W1983800116C2780062018 @default.
• W1983800116 hasConceptScore W1983800116C2780476085 @default.
• W1983800116 hasConceptScore W1983800116C2780494398 @default.
• W1983800116 hasConceptScore W1983800116C2780948584 @default.
• W1983800116 hasConceptScore W1983800116C44208683 @default.
• W1983800116 hasConceptScore W1983800116C513476851 @default.
• W1983800116 hasConceptScore W1983800116C529278444 @default.
• W1983800116 hasConceptScore W1983800116C55493867 @default.
• W1983800116 hasConceptScore W1983800116C71924100 @default.
• W1983800116 hasConceptScore W1983800116C98274493 @default.
• W1983800116 hasIssue "2" @default.
• W1983800116 hasLocation W19838001161 @default.

• next