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• W1983802078 abstract "In 7 non-smoking healthy volunteers, the number of micronuclei (MN) was determined in exfoliated buccal mucosa cells before and after rinsing the mouth with an aqueous 10 ppm solution of 2-trans-hexenal during 3 consecutive days. All individuals showed at least a doubling of the MN frequency during one of the next 4 days. An increase of the mean group MN frequency was observed on the fourth day, becoming significant between the sixth and the seventh day. During the next 2 days, the MN frequency dropped down to nearly the control level. In a second study, 7 other volunteers were examined before and after eating 3–6 bananas per day over a period of 3 days. The bananas contained about 35 ppm of hexenal. Six of the 7 individuals showed at least a doubling of the MN frequency during one of the next 6 days. An increase in the mean MN counts was also observed, but the difference to the control value became non-significant during the test period. The results show for the first time that the flavoring constituent 2-trans-hexenal, which is present in many human foods exerts genotoxic effects on human buccal mucosa cells in vivo." @default.
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• W1983802078 date "1997-04-01" @default.
• W1983802078 modified "2023-10-09" @default.
• W1983802078 title "Genotoxic effects of 2-trans-hexenal in human buccal mucosa cells in vivo" @default.
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• W1983802078 doi "https://doi.org/10.1016/s0165-1218(97)00013-x" @default.
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