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• W1983803873 abstract "<b><i>Background:</i></b> Life expectancy, as well as the average age of patients undergoing solid organ transplantation, increases constantly. Consequently, immunosuppressive therapy is no longer limited to young organ recipients. <b><i>Objective:</i></b> Here, we investigate how different types of immunosuppressive therapy, namely the calcineurin inhibitors cyclosporin A and tacrolimus, as well as the mTOR inhibitor rapamycin, affect the function of immune cells in young and elderly persons. <b><i>Methods:</i></b> Proliferation, cell viability, cytokine production (IL-2, IFN-&#947;), H₂O₂ production and telomere length of phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMCs) of young (n = 13; median age 27 years) and old (n = 19; median age 71 years) healthy donors were analyzed. <b><i>Results:</i></b> The inhibition of proliferation was dampened in PBMCs from elderly donors, especially after incubation with rapamycin. All three immunosuppressive drugs inhibited the production of IL-2 equally well, whereas the production of IFN-&#947; was less well inhibited by rapamycin. Both calcineurin inhibitors increased H₂O₂ concentrations after stimulation with PHA and led to a shortening of telomeres in PBMCs from young and old individuals. Rapamycin had only minor effects on H₂O₂ production and telomere length. <b><i>Conclusion:</i></b> Our results demonstrate that the effects of immunosuppressive drugs on PBMCs differ between young and elderly persons. Calcineurin inhibitors compared to rapamycin have a more pronounced prosenescence effect. These data indicate that specific treatment regimens for the elderly might therefore be considered." @default.
• W1983803873 created "2016-06-24" @default.
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• W1983803873 date "2014-01-01" @default.
• W1983803873 modified "2023-09-24" @default.
• W1983803873 title "Effect of Different Immunosuppressive Drugs on Immune Cells from Young and Old Healthy Persons" @default.
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• W1983803873 doi "https://doi.org/10.1159/000356020" @default.
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