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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983808266> ?p ?o ?g. }

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• W1983808266 abstract "Structure–activity relationships for the A-region in a series of N-4-t-butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamides as TRPV1 antagonists have been investigated. Among them, the 3-fluoro analogue 54 showed high binding affinity and potent antagonism for both rTRPV1 and hTRPV1 in CHO cells. Its stereospecific activity was demonstrated with marked selectivity for the (S)-configuration (54S versus 54R). A docking study of 54S with our hTRPV1 homology model highlighted crucial hydrogen bonds between the ligand and the receptor contributing to its potency." @default.
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• W1983808266 date "2012-01-01" @default.
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• W1983808266 title "N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure–activity relationships in the A-region" @default.
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• W1983808266 doi "https://doi.org/10.1016/j.bmc.2011.11.008" @default.
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