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- W1983813900 abstract "Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain, and the responsiveness of neurons to GABA can be modulated by sex steroids. To better understand how ovarian steroids influence the GABAergic system in the primate brain, we evaluated the expression of genes encoding GABA receptor subunits, glutamic acid decarboxylase (GAD) and a GABA transporter in the brains of female rhesus macaques. Ovariectomized adults were subjected to a hormone replacement paradigm involving either 17β-estradiol (E), or E plus progesterone (E + P). Untreated animals served as controls. Using GeneChip® microarray analysis and real-time RT-PCR (qPCR), we examined gene expression differences within and between the amygdala (AMD), hippocampus (HPC) and arcuate nuclei of the medial basal hypothalamus (MBH). The results from PCR corresponded with results from representative GeneChip® probesets, and showed similar effects of sex steroids on GABA receptor subunit gene expression in the AMD and HPC, and a more pronounced expression than in the MBH. Exposure to E + P attenuated GAD1, GAD2 and SLC32A1 gene expression in the AMD and HPC, but not in the MBH. GABA receptor subunit gene expression was generally higher in the AMD and HPC than in the MBH, with the exception of receptor subunits ɛ and γ2. Taken together, the data demonstrate differential regulation of GABA receptor subunits and GABAergic system components in the MBH compared to the AMD and HPC of rhesus macaques. Elevated ɛ and reduced δ subunit expression in the MBH supports the hypothesis that the hypothalamic GABAergic system is resistant to the modulatory effects of sex steroids." @default.
- W1983813900 created "2016-06-24" @default.
- W1983813900 creator A5004181866 @default.
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- W1983813900 creator A5049562137 @default.
- W1983813900 creator A5065801892 @default.
- W1983813900 creator A5066609115 @default.
- W1983813900 date "2010-01-01" @default.
- W1983813900 modified "2023-10-14" @default.
- W1983813900 title "Influence of 17β-estradiol and progesterone on GABAergic gene expression in the arcuate nucleus, amygdala and hippocampus of the rhesus macaque" @default.
- W1983813900 cites W1410347985 @default.
- W1983813900 cites W1502488470 @default.
- W1983813900 cites W1509009650 @default.
- W1983813900 cites W1574239291 @default.
- W1983813900 cites W1647312149 @default.
- W1983813900 cites W1654156243 @default.
- W1983813900 cites W1673072504 @default.
- W1983813900 cites W171396778 @default.
- W1983813900 cites W1771372085 @default.
- W1983813900 cites W1864733621 @default.
- W1983813900 cites W1898065702 @default.
- W1983813900 cites W1923851446 @default.
- W1983813900 cites W1950992052 @default.
- W1983813900 cites W1964328431 @default.
- W1983813900 cites W1965169456 @default.
- W1983813900 cites W1966695200 @default.
- W1983813900 cites W1969552181 @default.
- W1983813900 cites W1970208301 @default.
- W1983813900 cites W1970570515 @default.
- W1983813900 cites W1976995330 @default.
- W1983813900 cites W1977787204 @default.
- W1983813900 cites W1979467944 @default.
- W1983813900 cites W1985772728 @default.
- W1983813900 cites W1989257227 @default.
- W1983813900 cites W1989359395 @default.
- W1983813900 cites W1991773794 @default.
- W1983813900 cites W1992098768 @default.
- W1983813900 cites W1992679778 @default.
- W1983813900 cites W1994288348 @default.
- W1983813900 cites W1994645839 @default.
- W1983813900 cites W1996091531 @default.
- W1983813900 cites W1998362560 @default.
- W1983813900 cites W1999602956 @default.
- W1983813900 cites W2003407316 @default.
- W1983813900 cites W2003439788 @default.
- W1983813900 cites W2006646026 @default.
- W1983813900 cites W2006695602 @default.
- W1983813900 cites W2008277626 @default.
- W1983813900 cites W2008392190 @default.
- W1983813900 cites W2009010241 @default.
- W1983813900 cites W2009410204 @default.
- W1983813900 cites W2009512231 @default.
- W1983813900 cites W2012453718 @default.
- W1983813900 cites W2012667224 @default.
- W1983813900 cites W2013544816 @default.
- W1983813900 cites W2013920261 @default.
- W1983813900 cites W2014651639 @default.
- W1983813900 cites W2015229056 @default.
- W1983813900 cites W2017120126 @default.
- W1983813900 cites W2019718307 @default.
- W1983813900 cites W2020487122 @default.
- W1983813900 cites W2020714578 @default.
- W1983813900 cites W2020886601 @default.
- W1983813900 cites W2022549781 @default.
- W1983813900 cites W2023205562 @default.
- W1983813900 cites W2023527344 @default.
- W1983813900 cites W2024344189 @default.
- W1983813900 cites W2024394464 @default.
- W1983813900 cites W2027879303 @default.
- W1983813900 cites W2028058817 @default.
- W1983813900 cites W2030143382 @default.
- W1983813900 cites W2031856014 @default.
- W1983813900 cites W2033837647 @default.
- W1983813900 cites W2035244476 @default.
- W1983813900 cites W2035349243 @default.
- W1983813900 cites W2035790104 @default.
- W1983813900 cites W2037214866 @default.
- W1983813900 cites W2038415949 @default.
- W1983813900 cites W2038890115 @default.
- W1983813900 cites W2039738625 @default.
- W1983813900 cites W2041800714 @default.
- W1983813900 cites W2042563099 @default.
- W1983813900 cites W2049008567 @default.
- W1983813900 cites W2050243692 @default.
- W1983813900 cites W2053417960 @default.
- W1983813900 cites W2053928326 @default.
- W1983813900 cites W2061947653 @default.
- W1983813900 cites W2062186332 @default.
- W1983813900 cites W2062323242 @default.
- W1983813900 cites W2063524589 @default.
- W1983813900 cites W2063996780 @default.
- W1983813900 cites W2068781003 @default.
- W1983813900 cites W2068847189 @default.
- W1983813900 cites W2069927404 @default.
- W1983813900 cites W2070095465 @default.
- W1983813900 cites W2070510853 @default.
- W1983813900 cites W2071709232 @default.