Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983823417> ?p ?o ?g. }
- W1983823417 endingPage "3104" @default.
- W1983823417 startingPage "3094" @default.
- W1983823417 abstract "In Saccharomyces cerevisiae, deletion of the EST1 gene results in phenotypes identical to those displayed by a deletion of a known component of telomerase (the yeast telomerase RNA), arguing that EST1 is also critical for telomerase function. In this study, we show that the Estl protein binds to yeast G-rich telomeric oligonucleotides in vitro. Binding is specific for single-stranded substrates and requires a free 3' terminus, consistent with the properties expected for a protein bound to the 3' single-stranded G-rich extension present at the telomere. Assessment of the in vivo function of this single-stranded DNA-binding protein has shown that EST1 acts in the same pathway of telomere replication as the TLC1 telomerase RNA, by several different genetic criteria: est1 tlc1 double mutant strains show no enhancement of phenotype relative to either single mutant strain, and EST1 dominant mutations have an effect on telomeric silencing similar to that displayed by TLC1 previously. We propose that Est1 is a telomere end-binding protein that is required to mediate recognition of the end of the chromosome by telomerase." @default.
- W1983823417 created "2016-06-24" @default.
- W1983823417 creator A5043273992 @default.
- W1983823417 creator A5053210257 @default.
- W1983823417 creator A5076071801 @default.
- W1983823417 date "1996-12-15" @default.
- W1983823417 modified "2023-09-23" @default.
- W1983823417 title "Est1 has the properties of a single-stranded telomere end-binding protein." @default.
- W1983823417 cites W1863870645 @default.
- W1983823417 cites W1948628402 @default.
- W1983823417 cites W1966724584 @default.
- W1983823417 cites W1967390330 @default.
- W1983823417 cites W1970965142 @default.
- W1983823417 cites W1971361148 @default.
- W1983823417 cites W1972187528 @default.
- W1983823417 cites W1972303536 @default.
- W1983823417 cites W1973792844 @default.
- W1983823417 cites W1974306631 @default.
- W1983823417 cites W1975016572 @default.
- W1983823417 cites W1977780474 @default.
- W1983823417 cites W1981999122 @default.
- W1983823417 cites W1984352890 @default.
- W1983823417 cites W1988669405 @default.
- W1983823417 cites W1992842240 @default.
- W1983823417 cites W2004812565 @default.
- W1983823417 cites W2005576986 @default.
- W1983823417 cites W2010975156 @default.
- W1983823417 cites W2013712352 @default.
- W1983823417 cites W2015037479 @default.
- W1983823417 cites W2018089879 @default.
- W1983823417 cites W2018196617 @default.
- W1983823417 cites W2019705337 @default.
- W1983823417 cites W2019802887 @default.
- W1983823417 cites W2022959766 @default.
- W1983823417 cites W2023377008 @default.
- W1983823417 cites W2026856852 @default.
- W1983823417 cites W2041212841 @default.
- W1983823417 cites W2042432799 @default.
- W1983823417 cites W2045702252 @default.
- W1983823417 cites W2058346978 @default.
- W1983823417 cites W2069337628 @default.
- W1983823417 cites W2069406481 @default.
- W1983823417 cites W2073449926 @default.
- W1983823417 cites W2077449437 @default.
- W1983823417 cites W2083569841 @default.
- W1983823417 cites W2084140030 @default.
- W1983823417 cites W2085415499 @default.
- W1983823417 cites W2089362593 @default.
- W1983823417 cites W2089371695 @default.
- W1983823417 cites W2093321566 @default.
- W1983823417 cites W2099183600 @default.
- W1983823417 cites W2111723163 @default.
- W1983823417 cites W2122658576 @default.
- W1983823417 cites W2122740168 @default.
- W1983823417 cites W2123006322 @default.
- W1983823417 cites W2125572357 @default.
- W1983823417 cites W2126217681 @default.
- W1983823417 cites W2129709344 @default.
- W1983823417 cites W2143022342 @default.
- W1983823417 cites W2157984207 @default.
- W1983823417 cites W2175722093 @default.
- W1983823417 doi "https://doi.org/10.1101/gad.10.24.3094" @default.
- W1983823417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8985179" @default.
- W1983823417 hasPublicationYear "1996" @default.
- W1983823417 type Work @default.
- W1983823417 sameAs 1983823417 @default.
- W1983823417 citedByCount "144" @default.
- W1983823417 countsByYear W19838234172012 @default.
- W1983823417 countsByYear W19838234172013 @default.
- W1983823417 countsByYear W19838234172014 @default.
- W1983823417 countsByYear W19838234172015 @default.
- W1983823417 countsByYear W19838234172016 @default.
- W1983823417 countsByYear W19838234172018 @default.
- W1983823417 countsByYear W19838234172021 @default.
- W1983823417 crossrefType "journal-article" @default.
- W1983823417 hasAuthorship W1983823417A5043273992 @default.
- W1983823417 hasAuthorship W1983823417A5053210257 @default.
- W1983823417 hasAuthorship W1983823417A5076071801 @default.
- W1983823417 hasBestOaLocation W19838234171 @default.
- W1983823417 hasConcept C104317684 @default.
- W1983823417 hasConcept C119056186 @default.
- W1983823417 hasConcept C143065580 @default.
- W1983823417 hasConcept C153911025 @default.
- W1983823417 hasConcept C177336024 @default.
- W1983823417 hasConcept C202265312 @default.
- W1983823417 hasConcept C2777576037 @default.
- W1983823417 hasConcept C54355233 @default.
- W1983823417 hasConcept C552990157 @default.
- W1983823417 hasConcept C67705224 @default.
- W1983823417 hasConcept C86339819 @default.
- W1983823417 hasConcept C86803240 @default.
- W1983823417 hasConcept C94581717 @default.
- W1983823417 hasConcept C94966510 @default.
- W1983823417 hasConcept C95444343 @default.
- W1983823417 hasConceptScore W1983823417C104317684 @default.
- W1983823417 hasConceptScore W1983823417C119056186 @default.
- W1983823417 hasConceptScore W1983823417C143065580 @default.
- W1983823417 hasConceptScore W1983823417C153911025 @default.