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- W1983824614 abstract "Abstract A CC chemokine CCL18 stimulates collagen production in pulmonary fibroblasts through an unknown signaling mechanism. In this study, involvement of Sp1 and Smad3 in CCL18 signaling in primary human pulmonary fibroblast cultures was investigated. Phosphorylation of Sp1, DNA‐binding by Sp1, and the activity of an Sp1‐dependent reporter were all increased in response to CCL18 stimulation. CCL18 did not stimulate a detectable increase in Smad3 phosphorylation or Smad3/4 DNA‐binding activity, although some basal phosphorylation and DNA binding by Smad3/4 were noted. Transient overexpression of dominant negative mutants of Sp1 and Smad3 abrogated CCL18‐dependent upregulation as well as basal production of collagen. These observations suggested that CCL18 activates collagen production in pulmonary fibroblasts through an Sp1‐dependent pathway that also requires basal Smad3 activity. Possible involvement of autocrine TGF‐β in CCL18 signaling was considered. CCL18 stimulated increases in collagen mRNA and protein production without detectable changes in TGF‐β1, ‐β2, and ‐β3 mRNA or protein levels. Neutralizing anti‐TGF‐β antibodies, latency‐associated peptide, ALK5‐specific inhibitor SD431542, and an inhibitor of the protease‐dependent TGF‐β activation aprotinin, each failed to block CCL18‐stimulated collagen production. These observations suggest that both CCL18 signaling in pulmonary fibroblasts and basal Smad3 activity are independent of autocrine TGF‐β. © 2005 Wiley‐Liss, Inc." @default.
- W1983824614 created "2016-06-24" @default.
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- W1983824614 date "2005-07-14" @default.
- W1983824614 modified "2023-10-13" @default.
- W1983824614 title "CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity" @default.
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- W1983824614 doi "https://doi.org/10.1002/jcp.20452" @default.
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