FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983826897> ?p ?o ?g. }

• W1983826897 endingPage "273" @default.
• W1983826897 startingPage "273" @default.
• W1983826897 abstract "Complexes of general formula [PtCl2(NH3)L] with one radiosensitizing ligand per platinum are compared with ligand L alone, complexes with two radiosensitizers per platinum [PtCl2L2], and their analogs with NH3 ligands, with respect to radiosensitizing properties and toxicity in CHO cells. Radiosensitizing ligands, L, were misonidazole, metronidazole, 4(5)-nitroimidazole, and 2-amino-5-nitrothiazole, and the ammine analogs were cis- and trans-DDP [diamminedichloroplatinum(II)] and the monoammine, K[PtCl3(NH3)]. Results are related to a previous study on plasmid DNA binding by these series. The toxicity of the mono series [PtCl2(NH3)L], attributable to DNA binding, is much higher than the corresponding bis complexes, [PtCl2L2]. For L = misonidazole, toxicity is similar to the monoammine, but higher in hypoxic than in aerobic cells. trans-[PtCl2(NH3)-(misonidazole)] is more toxic than the cis isomer. Except for L = 4(5)-nitroimidazole, the complexes [PtCl2(NH3)L] are more toxic than L in air and hypoxia. Hypoxic radiosensitization by the mono complexes is comparable to the monoammine and is not better than free sensitizers, again except for L = 4(5)-nitroimidazole. Significantly lower sensitization is observed in oxic cells. The bis complexes [PtCl2L2], which do not bind to DNA as well as the mono complexes, are less effective radiosensitizers and less toxic than the [PtCl2(NH3)L] series." @default.
• W1983826897 created "2016-06-24" @default.
• W1983826897 creator A5052295498 @default.
• W1983826897 creator A5066264146 @default.
• W1983826897 creator A5079185884 @default.
• W1983826897 date "1987-11-01" @default.
• W1983826897 modified "2023-10-14" @default.
• W1983826897 title "Platinum Complexes with One Radiosensitizing Ligand [PtCl 2 (NH 3 ) (Sensitizer)]: Radiosensitization and Toxicity Studies in Vitro" @default.
• W1983826897 cites W1590117236 @default.
• W1983826897 cites W172338792 @default.
• W1983826897 cites W1754890121 @default.
• W1983826897 cites W1862292032 @default.
• W1983826897 cites W1969802219 @default.
• W1983826897 cites W1970048816 @default.
• W1983826897 cites W1974064825 @default.
• W1983826897 cites W1980285137 @default.
• W1983826897 cites W1981254356 @default.
• W1983826897 cites W1981709543 @default.
• W1983826897 cites W2008420221 @default.
• W1983826897 cites W2024444972 @default.
• W1983826897 cites W2029669573 @default.
• W1983826897 cites W2037508535 @default.
• W1983826897 cites W2041407539 @default.
• W1983826897 cites W2043731730 @default.
• W1983826897 cites W2056812813 @default.
• W1983826897 cites W2063277014 @default.
• W1983826897 cites W2067648947 @default.
• W1983826897 cites W2077221474 @default.
• W1983826897 cites W2094458872 @default.
• W1983826897 cites W2099478966 @default.
• W1983826897 cites W2151520426 @default.
• W1983826897 cites W2152480361 @default.
• W1983826897 cites W2165089070 @default.
• W1983826897 cites W2165822018 @default.
• W1983826897 cites W2166473873 @default.
• W1983826897 cites W2198890662 @default.
• W1983826897 cites W2317837479 @default.
• W1983826897 cites W2346285541 @default.
• W1983826897 cites W2492095109 @default.
• W1983826897 doi "https://doi.org/10.2307/3577255" @default.
• W1983826897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3685256" @default.
• W1983826897 hasPublicationYear "1987" @default.
• W1983826897 type Work @default.
• W1983826897 sameAs 1983826897 @default.
• W1983826897 citedByCount "24" @default.
• W1983826897 countsByYear W19838268972019 @default.
• W1983826897 countsByYear W19838268972021 @default.
• W1983826897 crossrefType "journal-article" @default.
• W1983826897 hasAuthorship W1983826897A5052295498 @default.
• W1983826897 hasAuthorship W1983826897A5066264146 @default.
• W1983826897 hasAuthorship W1983826897A5079185884 @default.
• W1983826897 hasConcept C116569031 @default.
• W1983826897 hasConcept C126322002 @default.
• W1983826897 hasConcept C155647269 @default.
• W1983826897 hasConcept C161790260 @default.
• W1983826897 hasConcept C170493617 @default.
• W1983826897 hasConcept C178790620 @default.
• W1983826897 hasConcept C185592680 @default.
• W1983826897 hasConcept C202751555 @default.
• W1983826897 hasConcept C2776428644 @default.
• W1983826897 hasConcept C2781047020 @default.
• W1983826897 hasConcept C2781305896 @default.
• W1983826897 hasConcept C29730261 @default.
• W1983826897 hasConcept C509974204 @default.
• W1983826897 hasConcept C518104683 @default.
• W1983826897 hasConcept C552990157 @default.
• W1983826897 hasConcept C55493867 @default.
• W1983826897 hasConcept C71240020 @default.
• W1983826897 hasConcept C71924100 @default.
• W1983826897 hasConceptScore W1983826897C116569031 @default.
• W1983826897 hasConceptScore W1983826897C126322002 @default.
• W1983826897 hasConceptScore W1983826897C155647269 @default.
• W1983826897 hasConceptScore W1983826897C161790260 @default.
• W1983826897 hasConceptScore W1983826897C170493617 @default.
• W1983826897 hasConceptScore W1983826897C178790620 @default.
• W1983826897 hasConceptScore W1983826897C185592680 @default.
• W1983826897 hasConceptScore W1983826897C202751555 @default.
• W1983826897 hasConceptScore W1983826897C2776428644 @default.
• W1983826897 hasConceptScore W1983826897C2781047020 @default.
• W1983826897 hasConceptScore W1983826897C2781305896 @default.
• W1983826897 hasConceptScore W1983826897C29730261 @default.
• W1983826897 hasConceptScore W1983826897C509974204 @default.
• W1983826897 hasConceptScore W1983826897C518104683 @default.
• W1983826897 hasConceptScore W1983826897C552990157 @default.
• W1983826897 hasConceptScore W1983826897C55493867 @default.
• W1983826897 hasConceptScore W1983826897C71240020 @default.
• W1983826897 hasConceptScore W1983826897C71924100 @default.
• W1983826897 hasIssue "2" @default.
• W1983826897 hasLocation W19838268971 @default.
• W1983826897 hasLocation W19838268972 @default.
• W1983826897 hasOpenAccess W1983826897 @default.
• W1983826897 hasPrimaryLocation W19838268971 @default.
• W1983826897 hasRelatedWork W1996770625 @default.
• W1983826897 hasRelatedWork W2015293626 @default.
• W1983826897 hasRelatedWork W2027010064 @default.
• W1983826897 hasRelatedWork W2045658902 @default.
• W1983826897 hasRelatedWork W2050628281 @default.
• W1983826897 hasRelatedWork W2054868631 @default.

• next