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- W1983830389 abstract "The in vivo absorption patterns of pure reserpine, a 1:5 w/w reserpine-polyvinylpyrrolidone physical mixture, and a 1:5 w/w reserpine-polyvinylpyrrolidone coprecipitate were compared by following the cumulative amounts of reserpine equivalents excreted in the urine as a function of time. The results of these urinary excretion studies demonstrated that both the rate and extent of absorption of reserpine in the rat were significantly enhanced following the oral administration of the coprecipitate; the fraction of the oral dose absorbed was three times greater with the 1:5 reserpine-polyvinylpyrrolidone coprecipitate than with either the pure drug or the 1:5 reserpine-polyvinylpyrrolidone physical mixture. The in vitro dissolution characteristics of the three test preparations at 37° correlated very well with the in vivo absorption data." @default.
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- W1983830389 date "1972-03-01" @default.
- W1983830389 modified "2023-09-23" @default.
- W1983830389 title "Enhanced Absorption and Dissolution of Reserpine from Reserpine-Polyvinylpyrrolidone Coprecipitates" @default.
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- W1983830389 doi "https://doi.org/10.1002/jps.2600610316" @default.
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