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• W1983832619 abstract "Modulation of inhibitory synaptic transmission within the central nervous system contributes considerably to the anaesthetic effects of propofol and its analogues in vivo. We have studied the effects of the non-anaesthetic propofol analogue 2,6-di-tert-butylphenol on rat alpha(1)beta(2)gamma(2) GABA(A) receptors expressed in a mammalian expression system (HEK 293 cells) using the whole-cell patch clamp technique. Our experiments showed that 2,6-di-tert-butylphenol completely lacks co-activation and direct activation of the inhibitory GABA(A) receptor. Our results support the assumption that modulation of inhibitory GABA(A) receptor function is responsible for the anaesthetic effects of propofol in vivo." @default.
• W1983832619 created "2016-06-24" @default.
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• W1983832619 date "2008-12-09" @default.
• W1983832619 modified "2023-09-22" @default.
• W1983832619 title "The Non-Anaesthetic Propofol Analogue 2,6-Di-tert-Butylphenol Fails to Modulate GABA_A Receptor Function" @default.
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• W1983832619 doi "https://doi.org/10.1159/000180125" @default.
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• W1983832619 hasPublicationYear "2008" @default.
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