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• W1983852511 abstract "A mixed polymeric micelle formulation of itraconazole (ITZ-PM) was prepared using monomethoxy poly(ethylene glycol)-b-poly(lactic acid) and poly(lactic acid) as drug carrier materials. The ITZ-PM formulation remarkably increased the itraconazole solubility up to 15 mg/mL in aqueous media and provided stable solutions at a wide range of concentrations and pH's. In toxicity studies of single and 28-day repeated administrations to rats and dogs, ITZ-PM was well tolerated at dose levels corresponding to clinical doses. The pharmacokinetic profiles of ITZ-PM for itraconazole and its major metabolite, hydroxy-itraconazole, were comparable to those of the cyclodextrin formulations (Sporanox® Injection and Oral Solution) in rats and dogs. These results suggest that ITZ-PM can be an advantageous formulation for both intravenous and oral routes." @default.
• W1983852511 created "2016-06-24" @default.
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• W1983852511 date "2007-01-01" @default.
• W1983852511 modified "2023-10-13" @default.
• W1983852511 title "A mixed polymeric micellar formulation of itraconazole: Characteristics, toxicity and pharmacokinetics" @default.
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• W1983852511 doi "https://doi.org/10.1016/j.jconrel.2006.10.001" @default.
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