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• W1983858621 abstract "The effect of 5 mg/p.o. mehylphenidate (MPH) challenge on β-endorphin (β-EP), growth hormone (GH), prolactin (Prl) and cortisol was investigated in 16 children suffering from attention deficit disorder with hyperactivity (ADDH) before and after 4 weeks MPH treatment. The study population consisted of 13 males and 3 females aged 6–11 years. All patients were drug free for at least 3 months prior to investigation. The severity of ADDH symptomatology and response to MPH chronic treatment was assessed using parent/teacher abbreviated Conners rating scale. Blood samples for β-EP, cortisol, Prl and GH were drawn before initiation of treatment (basal pre-treatment level), 2 hours after MPH challenge, 4 weeks after MPH treatment (basal post-treatment level) and 2 hours after re-challenge with MPH. Chronic MPH treatment resulted in a decrease in basal Prl levels (5.5 ± 2.8 vs 3.7 ± 1.9 ng/ml; p<0.05). Pre-treatment challenge stimulates significantly both β-EP (15.0 ± 7.5 vs 12.6 ± 5.3 pmol/1; p<0.05) and cortisol secretion (20.6 ± 6.6 vs 12.6 ± 5.8 μg/dl; p<0.05), and suppressed Prl secretion (4.0 ± 1.5 vs 5.5 ± 2.8 ng/ml; p<0.05). Re-challenge with MPH enhanced β-EP levels (14.9 ± 8.6 vs 10.6 ± 5.0 pmol/1; p<0.05) but failed to affect cortisol, Prl and GH secretion. The acute and chronic neuroendocrine effects of MPH administration might be related to its dopaminergic and adrenergic agonistic activity. It might be that the stimulatory effect of single and repeated acute MPH administration on β-EP release contributes to the beneficial effect of MPH treatment in ADDH children." @default.
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• W1983858621 date "1987-06-01" @default.
• W1983858621 modified "2023-10-16" @default.
• W1983858621 title "Effects of acute and chronic methylphenidate administration on β-endorphin, growth hormone, prolactin and cortisol in children with attention deficit disorder and hyperactivity" @default.
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• W1983858621 doi "https://doi.org/10.1016/0024-3205(87)90060-9" @default.
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