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- W1983881096 abstract "During visual system development, interactions between Eph tyrosine kinase receptors and their ligands, the ephrins, guide retinal ganglion cell (RGC) axons to their topographic targets in the optic tectum. Here we show that Eph/ephrin interactions are also involved in restoring topography during RGC axon regeneration in goldfish. Following optic nerve crush, EphA/ephrin-A interactions were blocked by intracranial injections of recombinant Eph receptor (EphA3-AP) or phospho-inositol phospholipase-C. Topographic errors with multiple inputs to some tectal loci were detected electrophysiologically and increased projections to caudal tectum demonstrated by RT-97 immunohistochemistry. In EphA3-AP-injected fish, ephrin-A2-expressing cells in the retino-recipient tectal layers were reduced in number compared to controls and their distribution was no longer graded. The findings, supported by in vitro studies, implicate EphA/ephrin-A interactions in restoring precise topography and in regulating ephrin-A2 expression during regeneration." @default.
- W1983881096 created "2016-06-24" @default.
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- W1983881096 date "2004-01-01" @default.
- W1983881096 modified "2023-10-10" @default.
- W1983881096 title "EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression" @default.
- W1983881096 cites W1490166600 @default.
- W1983881096 cites W1501558564 @default.
- W1983881096 cites W1513584485 @default.
- W1983881096 cites W1523167124 @default.
- W1983881096 cites W1526783389 @default.
- W1983881096 cites W1549831272 @default.
- W1983881096 cites W1575310353 @default.
- W1983881096 cites W1845362537 @default.
- W1983881096 cites W1876419231 @default.
- W1983881096 cites W1887547583 @default.
- W1983881096 cites W1950881526 @default.
- W1983881096 cites W1968979800 @default.
- W1983881096 cites W1971164610 @default.
- W1983881096 cites W1971717180 @default.
- W1983881096 cites W1974357562 @default.
- W1983881096 cites W1977249343 @default.
- W1983881096 cites W1980094138 @default.
- W1983881096 cites W1980593843 @default.
- W1983881096 cites W1982024326 @default.
- W1983881096 cites W1983134628 @default.
- W1983881096 cites W1984755886 @default.
- W1983881096 cites W1984882225 @default.
- W1983881096 cites W1985886471 @default.
- W1983881096 cites W1987152576 @default.
- W1983881096 cites W1988466044 @default.
- W1983881096 cites W1988490574 @default.
- W1983881096 cites W1990956997 @default.
- W1983881096 cites W1992764788 @default.
- W1983881096 cites W1994137567 @default.
- W1983881096 cites W1995261715 @default.
- W1983881096 cites W1998944071 @default.
- W1983881096 cites W1999871991 @default.
- W1983881096 cites W2001994631 @default.
- W1983881096 cites W2003445625 @default.
- W1983881096 cites W2016550440 @default.
- W1983881096 cites W2016977025 @default.
- W1983881096 cites W2021025315 @default.
- W1983881096 cites W2027051163 @default.
- W1983881096 cites W2027923445 @default.
- W1983881096 cites W2031930713 @default.
- W1983881096 cites W2034064964 @default.
- W1983881096 cites W2035595755 @default.
- W1983881096 cites W2037272215 @default.
- W1983881096 cites W2037641677 @default.
- W1983881096 cites W2038394965 @default.
- W1983881096 cites W2038478780 @default.
- W1983881096 cites W2042650229 @default.
- W1983881096 cites W2042902655 @default.
- W1983881096 cites W2043562994 @default.
- W1983881096 cites W2044977095 @default.
- W1983881096 cites W2053212962 @default.
- W1983881096 cites W2053721341 @default.
- W1983881096 cites W2054405029 @default.
- W1983881096 cites W2055307195 @default.
- W1983881096 cites W2059796270 @default.
- W1983881096 cites W2065934118 @default.
- W1983881096 cites W2074284246 @default.
- W1983881096 cites W2075269673 @default.
- W1983881096 cites W2081656219 @default.
- W1983881096 cites W2082156530 @default.
- W1983881096 cites W2082238044 @default.
- W1983881096 cites W2082581761 @default.
- W1983881096 cites W2090505541 @default.
- W1983881096 cites W2090861667 @default.
- W1983881096 cites W2093723806 @default.
- W1983881096 cites W2102270872 @default.
- W1983881096 cites W2103966995 @default.
- W1983881096 cites W2108613636 @default.
- W1983881096 cites W2120760119 @default.
- W1983881096 cites W2121952955 @default.
- W1983881096 cites W2125156606 @default.
- W1983881096 cites W2140067862 @default.
- W1983881096 cites W2155008209 @default.
- W1983881096 cites W2157585888 @default.
- W1983881096 cites W2157726561 @default.
- W1983881096 cites W2170562570 @default.
- W1983881096 cites W2171725531 @default.
- W1983881096 cites W2184257663 @default.
- W1983881096 cites W2327287238 @default.
- W1983881096 cites W2394907164 @default.
- W1983881096 cites W4377993708 @default.
- W1983881096 cites W2186135786 @default.
- W1983881096 doi "https://doi.org/10.1016/j.mcn.2003.09.010" @default.