FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983882412> ?p ?o ?g. }

• W1983882412 abstract "The aim of this work on rat hepatic P450 2E1 activity was to seek the most suitable experimental model to study the role of cytochrome P450 2E1 in the metabolism of industrial chemicals. Two sets of experiments were devoted to selecting the age and sex of animals and to estimating the response of male and female rats to different inducers. In the first set, the effect of three inducers (fasting; ethanol; acetone) was studied in male rats aged 5, 7 and 9 weeks. In the second set, the effect of different inducers, namely beta-naphthoflavone (BNF), phenobarbital (PB), ethanol, acetone and pyridine, on PNP and chlorzoxazone (CLZO) hydroxylase activities was studied in 7 week old male and female rats. The results demonstrate firstly that microsomal p-nitrophenol (PNP) hydroxylase activity significantly decreases in control male rats in inverse function of age, and secondly that induction by ethanol decreases with age. The PNP hydroxylase activity level of controls and the significant increases in PNP hydroxylase activity observed in 7 week old male rats show that this is the most suitable age for the second set of experiments. In this second set, it was shown that P450 1A (induced by BNF) is involved in CLZO hydroxylase activity only. PB increased the hydroxylase activities in male and female rats by about 1.5 and 1.7 times those of the controls, respectively. The effects of P450 2E1 inducers in function of sex show that male rats exhibited more significant increases in PNP and CLZO hydroxylase activities than female. The specificity of these two substrates is discussed. Neither of these two reactions was specifically catalysed by P450 2E1, but PNP may be considered as the most specific and the least sensitive substrate. In addition, the linear relationship observed between the two substrates (PNP and CLZO) showed a good correlation between their activities (r = 0.90, P < 0.001). In conclusion, these results suggest the use of the 7 week old male rat as the experimental model to study the role of cytochrome P450 2E1 in the hepatotoxicity of low molecular weight industrial chemicals." @default.
• W1983882412 created "2016-06-24" @default.
• W1983882412 creator A5037900498 @default.
• W1983882412 creator A5049686198 @default.
• W1983882412 creator A5052434242 @default.
• W1983882412 creator A5072841617 @default.
• W1983882412 date "1999-06-01" @default.
• W1983882412 modified "2023-10-14" @default.
• W1983882412 title "Evaluation of rat hepatic 2E1 activity in function of age, sex and inducers: choice of an experimental model capable of testing the hepatotoxicity of low molecular weight compounds" @default.
• W1983882412 cites W1577117187 @default.
• W1983882412 cites W1974103293 @default.
• W1983882412 cites W1975442768 @default.
• W1983882412 cites W1985670329 @default.
• W1983882412 cites W1992110429 @default.
• W1983882412 cites W1993554446 @default.
• W1983882412 cites W1996124369 @default.
• W1983882412 cites W1997048544 @default.
• W1983882412 cites W1999687129 @default.
• W1983882412 cites W1999855246 @default.
• W1983882412 cites W2008759580 @default.
• W1983882412 cites W2009695695 @default.
• W1983882412 cites W2012550708 @default.
• W1983882412 cites W2019039478 @default.
• W1983882412 cites W2022628424 @default.
• W1983882412 cites W2042289869 @default.
• W1983882412 cites W2042664740 @default.
• W1983882412 cites W2043708497 @default.
• W1983882412 cites W2052266375 @default.
• W1983882412 cites W2058151096 @default.
• W1983882412 cites W2059293500 @default.
• W1983882412 cites W2062178042 @default.
• W1983882412 cites W2064181764 @default.
• W1983882412 cites W2067303879 @default.
• W1983882412 cites W2068152038 @default.
• W1983882412 cites W2070779895 @default.
• W1983882412 cites W2078108692 @default.
• W1983882412 cites W2092086114 @default.
• W1983882412 cites W2093918159 @default.
• W1983882412 cites W2106245429 @default.
• W1983882412 cites W2119631951 @default.
• W1983882412 cites W2125411627 @default.
• W1983882412 cites W2132956283 @default.
• W1983882412 cites W2166848521 @default.
• W1983882412 doi "https://doi.org/10.1016/s0378-4274(99)00058-2" @default.
• W1983882412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10403661" @default.
• W1983882412 hasPublicationYear "1999" @default.
• W1983882412 type Work @default.
• W1983882412 sameAs 1983882412 @default.
• W1983882412 citedByCount "13" @default.
• W1983882412 countsByYear W19838824122013 @default.
• W1983882412 countsByYear W19838824122016 @default.
• W1983882412 countsByYear W19838824122017 @default.
• W1983882412 crossrefType "journal-article" @default.
• W1983882412 hasAuthorship W1983882412A5037900498 @default.
• W1983882412 hasAuthorship W1983882412A5049686198 @default.
• W1983882412 hasAuthorship W1983882412A5052434242 @default.
• W1983882412 hasAuthorship W1983882412A5072841617 @default.
• W1983882412 hasConcept C104317684 @default.
• W1983882412 hasConcept C126322002 @default.
• W1983882412 hasConcept C132154277 @default.
• W1983882412 hasConcept C134018914 @default.
• W1983882412 hasConcept C140027455 @default.
• W1983882412 hasConcept C181199279 @default.
• W1983882412 hasConcept C185592680 @default.
• W1983882412 hasConcept C2225953 @default.
• W1983882412 hasConcept C2776658834 @default.
• W1983882412 hasConcept C2778793413 @default.
• W1983882412 hasConcept C2780161600 @default.
• W1983882412 hasConcept C28212737 @default.
• W1983882412 hasConcept C526171541 @default.
• W1983882412 hasConcept C55493867 @default.
• W1983882412 hasConcept C62231903 @default.
• W1983882412 hasConcept C71924100 @default.
• W1983882412 hasConcept C87644729 @default.
• W1983882412 hasConceptScore W1983882412C104317684 @default.
• W1983882412 hasConceptScore W1983882412C126322002 @default.
• W1983882412 hasConceptScore W1983882412C132154277 @default.
• W1983882412 hasConceptScore W1983882412C134018914 @default.
• W1983882412 hasConceptScore W1983882412C140027455 @default.
• W1983882412 hasConceptScore W1983882412C181199279 @default.
• W1983882412 hasConceptScore W1983882412C185592680 @default.
• W1983882412 hasConceptScore W1983882412C2225953 @default.
• W1983882412 hasConceptScore W1983882412C2776658834 @default.
• W1983882412 hasConceptScore W1983882412C2778793413 @default.
• W1983882412 hasConceptScore W1983882412C2780161600 @default.
• W1983882412 hasConceptScore W1983882412C28212737 @default.
• W1983882412 hasConceptScore W1983882412C526171541 @default.
• W1983882412 hasConceptScore W1983882412C55493867 @default.
• W1983882412 hasConceptScore W1983882412C62231903 @default.
• W1983882412 hasConceptScore W1983882412C71924100 @default.
• W1983882412 hasConceptScore W1983882412C87644729 @default.
• W1983882412 hasLocation W19838824121 @default.
• W1983882412 hasLocation W19838824122 @default.
• W1983882412 hasOpenAccess W1983882412 @default.
• W1983882412 hasPrimaryLocation W19838824121 @default.
• W1983882412 hasRelatedWork W1968359841 @default.
• W1983882412 hasRelatedWork W1983882412 @default.
• W1983882412 hasRelatedWork W2007908110 @default.
• W1983882412 hasRelatedWork W2012550708 @default.
• W1983882412 hasRelatedWork W2015316225 @default.

• next