FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983882421> ?p ?o ?g. }

• W1983882421 endingPage "289" @default.
• W1983882421 startingPage "282" @default.
• W1983882421 abstract "Invasion plasmid antigen C (IpaC) is secreted by the Shigella flexneri type III secretion system (TTSS) as an essential trigger of epithelial cell invasion. At the molecular level, IpaC possesses a distinct functional organization. The IpaC C-terminal region between amino acids 319 and 345 is predicted to form a coiled-coil structure. Such alpha-helical motifs appear to be a recurring structural theme among TTSS components. Together with IpaB, this IpaC region is also required for the formation of translocon pores in target cell membranes. In contrast, mutations within the C-terminal tail of IpaC (defined by residues 345-363) have no effect on contact hemolysis (a putative measure of translocon pore formation), but they can contribute significantly to IpaC's ability to trigger S. flexneri entry into cultured cells. Here we describe the molecular dissection of the IpaC C-terminus and how changes in this region affect selected virulence-related activities. IpaC invasion function requires its immediate C-terminus and this general region may be involved in its ability to trigger actin nucleation. In contrast, IpaC could not be shown to interact directly with Cdc42, a host GTPase closely tied to Shigella invasion." @default.
• W1983882421 created "2016-06-24" @default.
• W1983882421 creator A5024201953 @default.
• W1983882421 creator A5024911011 @default.
• W1983882421 creator A5036177980 @default.
• W1983882421 creator A5055801144 @default.
• W1983882421 creator A5064087195 @default.
• W1983882421 creator A5070869869 @default.
• W1983882421 creator A5081589413 @default.
• W1983882421 date "2008-10-01" @default.
• W1983882421 modified "2023-10-16" @default.
• W1983882421 title "The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells" @default.
• W1983882421 cites W1591235242 @default.
• W1983882421 cites W1602426796 @default.
• W1983882421 cites W1687906393 @default.
• W1983882421 cites W1707316173 @default.
• W1983882421 cites W1989216986 @default.
• W1983882421 cites W1990963263 @default.
• W1983882421 cites W1994369382 @default.
• W1983882421 cites W1997119394 @default.
• W1983882421 cites W2003272265 @default.
• W1983882421 cites W2009804131 @default.
• W1983882421 cites W2020196783 @default.
• W1983882421 cites W2029852772 @default.
• W1983882421 cites W2038131958 @default.
• W1983882421 cites W2039650208 @default.
• W1983882421 cites W2047570774 @default.
• W1983882421 cites W2047570927 @default.
• W1983882421 cites W2058563463 @default.
• W1983882421 cites W2060690139 @default.
• W1983882421 cites W2083194472 @default.
• W1983882421 cites W2084708403 @default.
• W1983882421 cites W2086938468 @default.
• W1983882421 cites W2119568244 @default.
• W1983882421 cites W2121030642 @default.
• W1983882421 cites W2122203682 @default.
• W1983882421 cites W2123868514 @default.
• W1983882421 cites W2132639360 @default.
• W1983882421 cites W2133976150 @default.
• W1983882421 cites W2139063601 @default.
• W1983882421 cites W2141350298 @default.
• W1983882421 cites W2144384610 @default.
• W1983882421 cites W2161767156 @default.
• W1983882421 cites W2170543527 @default.
• W1983882421 cites W2170644493 @default.
• W1983882421 cites W2170671189 @default.
• W1983882421 doi "https://doi.org/10.1016/j.micpath.2008.06.003" @default.
• W1983882421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2581421" @default.
• W1983882421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18656530" @default.
• W1983882421 hasPublicationYear "2008" @default.
• W1983882421 type Work @default.
• W1983882421 sameAs 1983882421 @default.
• W1983882421 citedByCount "36" @default.
• W1983882421 countsByYear W19838824212012 @default.
• W1983882421 countsByYear W19838824212013 @default.
• W1983882421 countsByYear W19838824212014 @default.
• W1983882421 countsByYear W19838824212015 @default.
• W1983882421 countsByYear W19838824212016 @default.
• W1983882421 countsByYear W19838824212017 @default.
• W1983882421 countsByYear W19838824212019 @default.
• W1983882421 countsByYear W19838824212020 @default.
• W1983882421 countsByYear W19838824212021 @default.
• W1983882421 countsByYear W19838824212022 @default.
• W1983882421 crossrefType "journal-article" @default.
• W1983882421 hasAuthorship W1983882421A5024201953 @default.
• W1983882421 hasAuthorship W1983882421A5024911011 @default.
• W1983882421 hasAuthorship W1983882421A5036177980 @default.
• W1983882421 hasAuthorship W1983882421A5055801144 @default.
• W1983882421 hasAuthorship W1983882421A5064087195 @default.
• W1983882421 hasAuthorship W1983882421A5070869869 @default.
• W1983882421 hasAuthorship W1983882421A5081589413 @default.
• W1983882421 hasBestOaLocation W19838824212 @default.
• W1983882421 hasConcept C104317684 @default.
• W1983882421 hasConcept C130211564 @default.
• W1983882421 hasConcept C138626823 @default.
• W1983882421 hasConcept C199229279 @default.
• W1983882421 hasConcept C207332259 @default.
• W1983882421 hasConcept C2781217973 @default.
• W1983882421 hasConcept C49039625 @default.
• W1983882421 hasConcept C51785407 @default.
• W1983882421 hasConcept C547475151 @default.
• W1983882421 hasConcept C55493867 @default.
• W1983882421 hasConcept C60987743 @default.
• W1983882421 hasConcept C86803240 @default.
• W1983882421 hasConcept C89423630 @default.
• W1983882421 hasConcept C95444343 @default.
• W1983882421 hasConceptScore W1983882421C104317684 @default.
• W1983882421 hasConceptScore W1983882421C130211564 @default.
• W1983882421 hasConceptScore W1983882421C138626823 @default.
• W1983882421 hasConceptScore W1983882421C199229279 @default.
• W1983882421 hasConceptScore W1983882421C207332259 @default.
• W1983882421 hasConceptScore W1983882421C2781217973 @default.
• W1983882421 hasConceptScore W1983882421C49039625 @default.
• W1983882421 hasConceptScore W1983882421C51785407 @default.
• W1983882421 hasConceptScore W1983882421C547475151 @default.
• W1983882421 hasConceptScore W1983882421C55493867 @default.
• W1983882421 hasConceptScore W1983882421C60987743 @default.
• W1983882421 hasConceptScore W1983882421C86803240 @default.

• next