Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983884171> ?p ?o ?g. }
- W1983884171 endingPage "61" @default.
- W1983884171 startingPage "56" @default.
- W1983884171 abstract "We have earlier shown that cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients’ produces selective degeneration of motor neurons, both in vitro as well as in vivo. The present study further evaluates the effect of ALS–CSF on the astrocytes in embryonic rat spinal cord cultures. We quantified the number of flat and process-bearing astrocytes in spinal cord cultures exposed to ALS–CSF and compared them against controls. In addition, GFAP and S100β expression were quantified by Western blot and measurement of immunofluorescence intensity respectively. We found higher number of process-bearing astrocytes in the cultures exposed to ALS–CSF. Both these proteins increased significantly in cultures exposed to ALS–CSF. Our results provide evidence that astroglia respond to toxic factor(s) present in ALS–CSF by undergoing morphological transformation from flat to process bearing which is further confirmed by elevated expression of GFAP and S100β. The above changes could possibly alter the microenvironment hastening the motor neuron degeneration." @default.
- W1983884171 created "2016-06-24" @default.
- W1983884171 creator A5003910709 @default.
- W1983884171 creator A5005104742 @default.
- W1983884171 creator A5007152685 @default.
- W1983884171 creator A5026530949 @default.
- W1983884171 creator A5077695825 @default.
- W1983884171 date "2010-03-01" @default.
- W1983884171 modified "2023-10-16" @default.
- W1983884171 title "Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of astroglia and enhances GFAP and S100β expression" @default.
- W1983884171 cites W137838929 @default.
- W1983884171 cites W1852807375 @default.
- W1983884171 cites W1931706129 @default.
- W1983884171 cites W1968794985 @default.
- W1983884171 cites W1969373337 @default.
- W1983884171 cites W1973275674 @default.
- W1983884171 cites W1978874104 @default.
- W1983884171 cites W1986229796 @default.
- W1983884171 cites W1995689817 @default.
- W1983884171 cites W1996362183 @default.
- W1983884171 cites W2008560021 @default.
- W1983884171 cites W2009801706 @default.
- W1983884171 cites W2009831264 @default.
- W1983884171 cites W2012505933 @default.
- W1983884171 cites W2012851706 @default.
- W1983884171 cites W2015433283 @default.
- W1983884171 cites W2017523469 @default.
- W1983884171 cites W2019574772 @default.
- W1983884171 cites W2024497434 @default.
- W1983884171 cites W2025772577 @default.
- W1983884171 cites W2030654136 @default.
- W1983884171 cites W2032706712 @default.
- W1983884171 cites W2034038906 @default.
- W1983884171 cites W2038622543 @default.
- W1983884171 cites W2043717994 @default.
- W1983884171 cites W2046795642 @default.
- W1983884171 cites W2065843356 @default.
- W1983884171 cites W2066286044 @default.
- W1983884171 cites W2071695496 @default.
- W1983884171 cites W2074792377 @default.
- W1983884171 cites W2081879241 @default.
- W1983884171 cites W2082174518 @default.
- W1983884171 cites W2089390830 @default.
- W1983884171 cites W2092735317 @default.
- W1983884171 cites W2095635162 @default.
- W1983884171 cites W2135376726 @default.
- W1983884171 cites W2135522980 @default.
- W1983884171 cites W2154549928 @default.
- W1983884171 cites W2156171273 @default.
- W1983884171 cites W2160054680 @default.
- W1983884171 cites W2161938104 @default.
- W1983884171 doi "https://doi.org/10.1016/j.neulet.2010.02.022" @default.
- W1983884171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20170712" @default.
- W1983884171 hasPublicationYear "2010" @default.
- W1983884171 type Work @default.
- W1983884171 sameAs 1983884171 @default.
- W1983884171 citedByCount "25" @default.
- W1983884171 countsByYear W19838841712013 @default.
- W1983884171 countsByYear W19838841712014 @default.
- W1983884171 countsByYear W19838841712015 @default.
- W1983884171 countsByYear W19838841712016 @default.
- W1983884171 countsByYear W19838841712017 @default.
- W1983884171 countsByYear W19838841712018 @default.
- W1983884171 countsByYear W19838841712020 @default.
- W1983884171 countsByYear W19838841712022 @default.
- W1983884171 countsByYear W19838841712023 @default.
- W1983884171 crossrefType "journal-article" @default.
- W1983884171 hasAuthorship W1983884171A5003910709 @default.
- W1983884171 hasAuthorship W1983884171A5005104742 @default.
- W1983884171 hasAuthorship W1983884171A5007152685 @default.
- W1983884171 hasAuthorship W1983884171A5026530949 @default.
- W1983884171 hasAuthorship W1983884171A5077695825 @default.
- W1983884171 hasConcept C104317684 @default.
- W1983884171 hasConcept C142724271 @default.
- W1983884171 hasConcept C169760540 @default.
- W1983884171 hasConcept C203014093 @default.
- W1983884171 hasConcept C204232928 @default.
- W1983884171 hasConcept C2776415932 @default.
- W1983884171 hasConcept C2776752467 @default.
- W1983884171 hasConcept C2776914184 @default.
- W1983884171 hasConcept C2777542381 @default.
- W1983884171 hasConcept C2779134260 @default.
- W1983884171 hasConcept C2779651940 @default.
- W1983884171 hasConcept C2779830541 @default.
- W1983884171 hasConcept C2780495277 @default.
- W1983884171 hasConcept C2780596555 @default.
- W1983884171 hasConcept C2780775167 @default.
- W1983884171 hasConcept C2780884517 @default.
- W1983884171 hasConcept C529278444 @default.
- W1983884171 hasConcept C55493867 @default.
- W1983884171 hasConcept C71924100 @default.
- W1983884171 hasConcept C86803240 @default.
- W1983884171 hasConcept C87753298 @default.
- W1983884171 hasConceptScore W1983884171C104317684 @default.
- W1983884171 hasConceptScore W1983884171C142724271 @default.
- W1983884171 hasConceptScore W1983884171C169760540 @default.
- W1983884171 hasConceptScore W1983884171C203014093 @default.
- W1983884171 hasConceptScore W1983884171C204232928 @default.