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• W1983886109 abstract "Summary Factor XI ( FXI )‐deficient patients may develop excessive bleeding after trauma or surgery. Replacement therapy should be considered in high‐risk situations, especially when FXI levels are below 20 IU dL −1 . HEMOLEVEN is a human plasma‐derived factor XI concentrate available in France since 1992, but there are few data regarding its use by physicians. This prospective study assessed the use, efficacy and safety of HEMOLEVEN in common clinical practice. HEMOLEVEN was evaluated in FXI ‐deficient patients in 13 French centres in a 3‐year postmarketing study. Forty‐four patients (30 females, 14 males) received 67 treatments. The median age was 37 years (8 months–91 years). Basal FXI levels were <1 to 51 IU dL −1 (median: 5.5); 29 patients were severely FXI ‐deficient (<20 IU dL −1 ). FXI was administered prophylactically before 43 surgical procedures, 10 invasive procedures, 8 vaginal deliveries, or as curative treatment for six bleeds. The efficacy was assessed as excellent/good in 63, moderate in two and undetermined in two treatments. Seven patients experienced seven adverse effects, including two rated as serious: one sudden massive pulmonary embolism with fatal outcome and one case of inhibitor to FXI . HEMOLEVEN is effective for bleeding prevention in FXI deficiency. However, considering the benefit/risk ratio observed in relation to dosage in this study; firstly, it should be used sparingly due to its potential prothrombotic effect; secondly, new prescription procedures should be defined to adapt the dosage, especially in patients with intrinsic and/or acquired risk factors for thrombosis." @default.
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• W1983886109 date "2015-03-26" @default.
• W1983886109 modified "2023-10-17" @default.
• W1983886109 title "Factor <scp>XI</scp> replacement for inherited factor <scp>XI</scp> deficiency in routine clinical practice: results of the <scp>HEMOLEVEN</scp> prospective 3‐year postmarketing study" @default.
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• W1983886109 doi "https://doi.org/10.1111/hae.12655" @default.
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