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• W1983886338 endingPage "3983" @default.
• W1983886338 startingPage "3959" @default.
• W1983886338 abstract "In any comparative studies striving to understand the similarities and differences of the living organisms at the molecular genetic level, the crucial first step is to establish the homology (orthology and paralogy) of genes between different organisms. Determination of the homology of genes becomes complicated when the genes have undergone a rapid divergence in sequence or when the involved genes are members of a gene family that has experienced a differential gain or loss of its constituents in different taxonomic groups. Organisms with duplicated genomes such as teleost fishes might have been especially prone to these problems because the functional redundancies provided by the duplicate copies of genes would have allowed a rapid divergence or loss of genes during evolution. In this study, we will demonstrate that much of the ambiguities in the determination of the homology between fish and tetrapod genes resulting from the problems like these can be eliminated by complementing the sequence-based phylogenies with nonsequence information, such as the exon–intron structure of a gene or the composition of a gene’s genomic neighbors. We will use the Tbx6/16 subfamily genes of zebrafish (tbx6, tbx16, tbx24, and mga genes), which have been well known for the ambiguity of their evolutionary relationships to the Tbx6/16 subfamily genes of tetrapods, as an illustrative example. We will show that, despite the similarity of sequence and expression to the tetrapod Tbx6 genes, zebrafish tbx6 gene is actually a novel T-box gene more closely related to the tetrapod Tbx16 genes, whereas the zebrafish tbx24 gene, hitherto considered to be a novel gene due to the high level of sequence divergence, is actually an ortholog of tetrapod Tbx6 genes. We will also show that, after their initial appearance by the multiplication of a common ancestral gene at the beginning of vertebrate evolution, the Tbx6/16 subfamily of vertebrate T-box genes might have experienced differential losses of member genes in different vertebrate groups and gradual pooling of member gene’s functions in surviving members, which might have prevented the revelation of the true identity of member genes by way of the comparison of sequence and function." @default.
• W1983886338 created "2016-06-24" @default.
• W1983886338 creator A5000532863 @default.
• W1983886338 creator A5033974090 @default.
• W1983886338 creator A5036223441 @default.
• W1983886338 date "2012-08-21" @default.
• W1983886338 modified "2023-10-16" @default.
• W1983886338 title "Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish" @default.
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