FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983889201> ?p ?o ?g. }

• W1983889201 endingPage "903" @default.
• W1983889201 startingPage "894" @default.
• W1983889201 abstract "Accumulating evidence suggests a critical role of increased reactive oxygen species production for left ventricular (LV) remodeling and dysfunction after myocardial infarction (MI). An increased myocardial activity of the NAD(P)H oxidase, a major oxidant enzyme system, has been observed in human heart failure; however, the role of the NAD(P)H oxidase for LV remodeling and dysfunction after MI remains to be determined. MI was induced in wild-type (WT) mice (n=46) and mice lacking the cytosolic NAD(P)H oxidase component p47 phox (p47 phox −/− mice) (n=32). Infarct size was similar among the groups. NAD(P)H oxidase activity was markedly increased in remote LV myocardium of WT mice after MI as compared with sham-operated mice (83±8 versus 16.7±3.5 nmol of O 2 − · μg −1 ·min −1 ; P <0.01) but not in p47 phox −/− mice after MI (13.5±3.6 versus 15.5±3.5 nmol of O 2 − · μg −1 ·min −1 ), as assessed by electron-spin resonance spectroscopy using the spin probe CP-H. Furthermore, increased myocardial xanthine oxidase activity was observed in WT, but not in p47 phox −/− mice after MI, suggesting NAD(P)H oxidase–dependent xanthine oxidase activation. Myocardial reactive oxygen species production was increased in WT mice, but not in p47 phox −/− mice, after MI. LV cavity dilatation and dysfunction 4 weeks after MI were markedly attenuated in p47 phox −/− mice as compared with WT mice, as assessed by echocardiography (LV end-diastolic diameter: 4.5±0.2 versus 6.3±0.3 mm, P <0.01; LV ejection fraction, 35.8±2.5 versus 22.6±4.4%, P <0.05). Furthermore, cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis were substantially reduced in p47 phox −/− mice as compared with WT mice. Importantly, the survival rate was markedly higher in p47 phox −/− mice as compared with WT mice after MI (72% versus 48%; P <0.05). These results suggest a pivotal role of NAD(P)H oxidase activation and its subunit p47 phox for LV remodeling/dysfunction and survival after MI. The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI." @default.
• W1983889201 created "2016-06-24" @default.
• W1983889201 creator A5000116094 @default.
• W1983889201 creator A5009727982 @default.
• W1983889201 creator A5015024142 @default.
• W1983889201 creator A5017901289 @default.
• W1983889201 creator A5030151463 @default.
• W1983889201 creator A5056552919 @default.
• W1983889201 creator A5065450312 @default.
• W1983889201 creator A5066349732 @default.
• W1983889201 creator A5072531556 @default.
• W1983889201 creator A5074006232 @default.
• W1983889201 creator A5080753934 @default.
• W1983889201 date "2007-03-30" @default.
• W1983889201 modified "2023-10-17" @default.
• W1983889201 title "Critical Role of the NAD(P)H Oxidase Subunit p47 ^<i>phox</i> for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction" @default.
• W1983889201 cites W1929253030 @default.
• W1983889201 cites W1967970013 @default.
• W1983889201 cites W1974614602 @default.
• W1983889201 cites W1980322984 @default.
• W1983889201 cites W1987037786 @default.
• W1983889201 cites W2010032368 @default.
• W1983889201 cites W2023578446 @default.
• W1983889201 cites W2029543479 @default.
• W1983889201 cites W2030437438 @default.
• W1983889201 cites W2051451432 @default.
• W1983889201 cites W2069249788 @default.
• W1983889201 cites W2082452850 @default.
• W1983889201 cites W2090414072 @default.
• W1983889201 cites W2099120495 @default.
• W1983889201 cites W2099136646 @default.
• W1983889201 cites W2104645386 @default.
• W1983889201 cites W2108235369 @default.
• W1983889201 cites W2111529958 @default.
• W1983889201 cites W2117489997 @default.
• W1983889201 cites W2118287470 @default.
• W1983889201 cites W2119494775 @default.
• W1983889201 cites W2126129355 @default.
• W1983889201 cites W2129048293 @default.
• W1983889201 cites W2130999379 @default.
• W1983889201 cites W2132039169 @default.
• W1983889201 cites W2135802281 @default.
• W1983889201 cites W2148598977 @default.
• W1983889201 cites W2154295247 @default.
• W1983889201 cites W2161189845 @default.
• W1983889201 cites W2163582362 @default.
• W1983889201 cites W2167840450 @default.
• W1983889201 cites W2169937658 @default.
• W1983889201 cites W2170551438 @default.
• W1983889201 cites W2171466485 @default.
• W1983889201 cites W4247794967 @default.
• W1983889201 doi "https://doi.org/10.1161/01.res.0000261657.76299.ff" @default.
• W1983889201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17332431" @default.
• W1983889201 hasPublicationYear "2007" @default.
• W1983889201 type Work @default.
• W1983889201 sameAs 1983889201 @default.
• W1983889201 citedByCount "198" @default.
• W1983889201 countsByYear W19838892012012 @default.
• W1983889201 countsByYear W19838892012013 @default.
• W1983889201 countsByYear W19838892012014 @default.
• W1983889201 countsByYear W19838892012015 @default.
• W1983889201 countsByYear W19838892012016 @default.
• W1983889201 countsByYear W19838892012017 @default.
• W1983889201 countsByYear W19838892012018 @default.
• W1983889201 countsByYear W19838892012019 @default.
• W1983889201 countsByYear W19838892012020 @default.
• W1983889201 countsByYear W19838892012021 @default.
• W1983889201 countsByYear W19838892012022 @default.
• W1983889201 countsByYear W19838892012023 @default.
• W1983889201 crossrefType "journal-article" @default.
• W1983889201 hasAuthorship W1983889201A5000116094 @default.
• W1983889201 hasAuthorship W1983889201A5009727982 @default.
• W1983889201 hasAuthorship W1983889201A5015024142 @default.
• W1983889201 hasAuthorship W1983889201A5017901289 @default.
• W1983889201 hasAuthorship W1983889201A5030151463 @default.
• W1983889201 hasAuthorship W1983889201A5056552919 @default.
• W1983889201 hasAuthorship W1983889201A5065450312 @default.
• W1983889201 hasAuthorship W1983889201A5066349732 @default.
• W1983889201 hasAuthorship W1983889201A5072531556 @default.
• W1983889201 hasAuthorship W1983889201A5074006232 @default.
• W1983889201 hasAuthorship W1983889201A5080753934 @default.
• W1983889201 hasBestOaLocation W19838892011 @default.
• W1983889201 hasConcept C126322002 @default.
• W1983889201 hasConcept C134018914 @default.
• W1983889201 hasConcept C181199279 @default.
• W1983889201 hasConcept C185592680 @default.
• W1983889201 hasConcept C2776151105 @default.
• W1983889201 hasConcept C2778102346 @default.
• W1983889201 hasConcept C2778198053 @default.
• W1983889201 hasConcept C2779537366 @default.
• W1983889201 hasConcept C2779719074 @default.
• W1983889201 hasConcept C2781252958 @default.
• W1983889201 hasConcept C38485361 @default.
• W1983889201 hasConcept C48349386 @default.
• W1983889201 hasConcept C500558357 @default.
• W1983889201 hasConcept C55493867 @default.
• W1983889201 hasConcept C71924100 @default.
• W1983889201 hasConcept C75520062 @default.

• next