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- W1983929551 abstract "No known meaningful health risks have been reported following the use of microbubble ultrasound echogenic contrast imaging agents in the United States. We designed a preliminary study to examine the potential for injury to endothelial cells in vivo following the interaction of intravascular contrast agent with ultrasound. We used a focused f/1 3.1-MHz, transducer that had in situ (at the skin) peak rarefactional and compressional pressures of 20 MPa and 46 MPa, respectively, 1.0-kHz PRF, 1.2-μs pulse duration, 180-s exposure duration, and MI of 5.8. The central auricular artery of a rabbit ear was exposed and then contrast agent administered intravenously in the lateral vein of the contralateral ear. The central auricular artery was again exposed to ultrasound at additional sites. No significant lesions were observed in arteries of rabbits evaluated immediately following exposure. When evaluated 24 or more hours after exposure, necrosis of vascular endothelial cells and subjacent smooth muscle cells, early reparative responses, leukocyte margination, and thrombosis were observed. Because of the wide use of echocardiography and contrast agents, the described vascular phenomena need additional evaluation for short and long term effects related to thrombosis and atherosclerosis in at risk patients. [Supported by NIH Grant No. HL58218.]" @default.
- W1983929551 created "2016-06-24" @default.
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- W1983929551 date "2001-05-01" @default.
- W1983929551 modified "2023-09-25" @default.
- W1983929551 title "Potential for contrast agent‐induced endothelial cell injury in rabbit arteries exposed to pulsed ultrasound" @default.
- W1983929551 doi "https://doi.org/10.1121/1.4744711" @default.
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