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• W1983929924 startingPage "338" @default.
• W1983929924 abstract "To analyse the 5'-flanking sequences required for the tissue specific transcription of the human erythropoietin receptor (hEpo-R) gene, a DNA region spanning nucleotides -1050 to +135 relative to the transcription initiation site (+1) was explored. Our studies indicate that a minimum promoter (-76/+33) containing GATA and SP1 binding sites at positions -45 and -20 is not sufficient to confer erythroid specific expression to a reporter gene. Erythroid specificity of the promoter was observed either with the (-1050/+33 construct) which contains a cluster of Alu repetitive elements or with the addition of the 135 bp down to the transcription initiation site (-76/+135 construct) which exert a negative control on the promoter activity with a major effect in non erythroid tissues. The latter region can be subdivided on two distinct domains: the +1/+78 region that exerts a positive effect and the +79/+135 region that has a negative effect on the Epo-R promoter activity measured by CAT assays. The first region contains three CANNTG motifs, whereas the second contains an SP1/CACCC motif at position +85. These findings reveal a complex regulation of the hEpo-R gene and provide a working model useful to explain how the minimal promoter, containing GATA/SP1, can be positively and negatively regulated during erythroid differentiation." @default.
• W1983929924 created "2016-06-24" @default.
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• W1983929924 date "1994-01-01" @default.
• W1983929924 modified "2023-10-18" @default.
• W1983929924 title "Different domains regulate the human erythropoietin receptor gene transcription" @default.
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• W1983929924 doi "https://doi.org/10.1093/nar/22.3.338" @default.
• W1983929924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/523586" @default.
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• W1983929924 hasPublicationYear "1994" @default.
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