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- W1983938177 abstract "Hydrophobic bisphosphate amidated derivatives (1a–1d) anchored long alkyl chains were designed and obtained through the reaction of -NH 2 in BPs and -COOH in fat acid under anhydrous condition. The structure of derivatives were investigated by fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and mass spectrometer (MS) and the results showed that the final products were amidated compounds with the long alkyl anchored in alendroante's lateral chain R 2 . The physicochemical parameters, such as the solubility and partition coefficient in n-octanol/water, were also determined through calculated by performing reversed phase high performance liquid chromatography (RP-HPLC). Compared with alendronate, the derivatives had a very low aqueous solubility and had little or even no measurable solubility values in PBS. While it had different solubility in organic solvents with different polarities. The partition coefficient P o/w of derivatives in n-octacol/water mixture was calculated and the results showed that the derivatives had the high P o/w data than that of alendronate and the longer the alkyl chain was introduced, the higher the partition coefficient was. All of the above results showed the improved lipophilicity of the derivatives through long alkyl chain introduced into its R 2 chain." @default.
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- W1983938177 date "2011-06-01" @default.
- W1983938177 modified "2023-09-26" @default.
- W1983938177 title "Synthesis and physicochemical property of the hydrophobic bisphosphate amidated derivatives" @default.
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- W1983938177 doi "https://doi.org/10.1109/rsete.2011.5964179" @default.
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