FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983957619> ?p ?o ?g. }

• W1983957619 endingPage "3024" @default.
• W1983957619 startingPage "3003" @default.
• W1983957619 abstract "G Protein Coupled Receptors (GPCRs) are the largest family of receptors whose ligands constitute nearly a third of prescription drugs in the market. They are widely involved in diverse physiological functions including learning and memory. NMDA receptors (NMDARs), which belong to the ionotropic glutamate receptor family, are likewise ubiquitously expressed in the central nervous system (CNS) and play a pivotal role in learning and memory. Despite its critical contribution to physiological and pathophysiological processes, few pharmacological interventions aimed directly at regulating NMDAR function have been developed to date. However, it is well established that NMDAR function is precisely regulated by cellular signalling cascades recruited downstream of G protein coupled receptor (GPCR) stimulation. Accordingly, the downstream regulation of NMDARs likely represents an important determinant of outcome following treatment with neuropsychiatric agents that target selected GPCRs. Importantly, the functional consequence of such regulation on NMDAR function varies, based not only on the identity of the GPCR, but also on the cell type in which relevant receptors are expressed. Indeed, the mechanisms responsible for regulating NMDARs by GPCRs involve numerous intracellular signalling molecules and regulatory proteins that vary from one cell type to another. In the present article, we highlight recent findings from studies that have uncovered novel mechanisms by which selected GPCRs regulate NMDAR function and consequently NMDAR-dependent plasticity." @default.
• W1983957619 created "2016-06-24" @default.
• W1983957619 creator A5006034052 @default.
• W1983957619 creator A5018022392 @default.
• W1983957619 creator A5064607593 @default.
• W1983957619 date "2014-02-20" @default.
• W1983957619 modified "2023-10-06" @default.
• W1983957619 title "Recent Progress in Understanding Subtype Specific Regulation of NMDA Receptors by G Protein Coupled Receptors (GPCRs)" @default.
• W1983957619 cites W106733242 @default.
• W1983957619 cites W1498691783 @default.
• W1983957619 cites W1527134354 @default.
• W1983957619 cites W1532214820 @default.
• W1983957619 cites W1543655975 @default.
• W1983957619 cites W1547104500 @default.
• W1983957619 cites W1603191004 @default.
• W1983957619 cites W1603274157 @default.
• W1983957619 cites W1656913045 @default.
• W1983957619 cites W1758193981 @default.
• W1983957619 cites W1772604871 @default.
• W1983957619 cites W1869926743 @default.
• W1983957619 cites W1876061808 @default.
• W1983957619 cites W1932691040 @default.
• W1983957619 cites W1960769979 @default.
• W1983957619 cites W1964647417 @default.
• W1983957619 cites W1967545898 @default.
• W1983957619 cites W1970851711 @default.
• W1983957619 cites W1972270334 @default.
• W1983957619 cites W1972884505 @default.
• W1983957619 cites W1978846005 @default.
• W1983957619 cites W1984858305 @default.
• W1983957619 cites W1985241009 @default.
• W1983957619 cites W1987055937 @default.
• W1983957619 cites W1994217011 @default.
• W1983957619 cites W1995906542 @default.
• W1983957619 cites W1998349282 @default.
• W1983957619 cites W1998388607 @default.
• W1983957619 cites W2003701228 @default.
• W1983957619 cites W2003875374 @default.
• W1983957619 cites W2006541920 @default.
• W1983957619 cites W2006909079 @default.
• W1983957619 cites W2007393704 @default.
• W1983957619 cites W2009796900 @default.
• W1983957619 cites W2010599721 @default.
• W1983957619 cites W2011331399 @default.
• W1983957619 cites W2012641732 @default.
• W1983957619 cites W2013374077 @default.
• W1983957619 cites W2014408809 @default.
• W1983957619 cites W2014869384 @default.
• W1983957619 cites W2024210610 @default.
• W1983957619 cites W2024380057 @default.
• W1983957619 cites W2024752098 @default.
• W1983957619 cites W2028594041 @default.
• W1983957619 cites W2030126027 @default.
• W1983957619 cites W2030756376 @default.
• W1983957619 cites W2030868502 @default.
• W1983957619 cites W2032790231 @default.
• W1983957619 cites W2034823208 @default.
• W1983957619 cites W2035252993 @default.
• W1983957619 cites W2037736511 @default.
• W1983957619 cites W2039348342 @default.
• W1983957619 cites W2045895646 @default.
• W1983957619 cites W2047912472 @default.
• W1983957619 cites W2048766805 @default.
• W1983957619 cites W2049517532 @default.
• W1983957619 cites W2050307742 @default.
• W1983957619 cites W2052100818 @default.
• W1983957619 cites W2052488789 @default.
• W1983957619 cites W2055211586 @default.
• W1983957619 cites W2057990190 @default.
• W1983957619 cites W2060202251 @default.
• W1983957619 cites W2061648961 @default.
• W1983957619 cites W2063206977 @default.
• W1983957619 cites W2064111585 @default.
• W1983957619 cites W2065940220 @default.
• W1983957619 cites W2067415178 @default.
• W1983957619 cites W2068441555 @default.
• W1983957619 cites W2070331365 @default.
• W1983957619 cites W2071090720 @default.
• W1983957619 cites W2073831388 @default.
• W1983957619 cites W2075752641 @default.
• W1983957619 cites W2078167209 @default.
• W1983957619 cites W2078662595 @default.
• W1983957619 cites W2078729100 @default.
• W1983957619 cites W2080213202 @default.
• W1983957619 cites W2081788716 @default.
• W1983957619 cites W2083277982 @default.
• W1983957619 cites W2084993455 @default.
• W1983957619 cites W2086007196 @default.
• W1983957619 cites W2086543171 @default.
• W1983957619 cites W2088239473 @default.
• W1983957619 cites W2088307620 @default.
• W1983957619 cites W2089211424 @default.
• W1983957619 cites W2093034752 @default.
• W1983957619 cites W2093522308 @default.
• W1983957619 cites W2095213614 @default.
• W1983957619 cites W2096562774 @default.
• W1983957619 cites W2098560279 @default.
• W1983957619 cites W2103848983 @default.

• next