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• W1983966505 abstract "Lactobacillus delbrueckii ssp. bulgaricus ( L. bulgaricus ) is a representative of the group of lactic acid-producing bacteria, mainly known for its worldwide application in yogurt production. The genome sequence of this bacterium has been determined and shows the signs of ongoing specialization, with a substantial number of pseudogenes and incomplete metabolic pathways and relatively few regulatory functions. Several unique features of the L. bulgaricus genome support the hypothesis that the genome is in a phase of rapid evolution. ( i ) Exceptionally high numbers of rRNA and tRNA genes with regard to genome size may indicate that the L. bulgaricus genome has known a recent phase of important size reduction, in agreement with the observed high frequency of gene inactivation and elimination; ( ii ) a much higher GC content at codon position 3 than expected on the basis of the overall GC content suggests that the composition of the genome is evolving toward a higher GC content; and ( iii ) the presence of a 47.5-kbp inverted repeat in the replication termination region, an extremely rare feature in bacterial genomes, may be interpreted as a transient stage in genome evolution. The results indicate the adaptation of L. bulgaricus from a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation with Streptococcus thermophilus ." @default.
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• W1983966505 date "2006-06-13" @default.
• W1983966505 modified "2023-09-30" @default.
• W1983966505 title "The complete genome sequence of <i>Lactobacillus bulgaricus</i> reveals extensive and ongoing reductive evolution" @default.
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• W1983966505 doi "https://doi.org/10.1073/pnas.0603024103" @default.
• W1983966505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1482600" @default.
• W1983966505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16754859" @default.
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