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• W1983973807 endingPage "7702" @default.
• W1983973807 startingPage "7691" @default.
• W1983973807 abstract "Mammalian Aurora-A is related to a serine/threonine protein kinase that was originally identified by its close homology with Saccharomyces cerevisiae Ipl1p and Drosophila melanogaster aurora that are key regulators in the orchestration of mitotic events. The protein level of Aurora-A, its peak kinase activity during mitosis, and its activation have been attributed to phosphorylation. Here we show that this enzyme is an arginine-directed kinase and define its substrate specificity. We also found that Thr288 within the activation loop is a critical residue for activating phosphorylation events in vitro and that it is spatiotemporally restricted to a brief window at mitosis on duplicated centrosomes and on spindle microtubules proximal to the poles in vivo. Immunodepletion assays indicated that an upstream kinase(s) of Aurora-A might exist in mammalian cells in addition to autophosphorylation. Furthermore, human activated Aurora-A forms complexes with the negative regulator protein serine/threonine phosphatase type 1 (PP1) that was negatively phosphorylated on Thr320. Interestingly, phospho-specific Aurora-A monoclonal antibodies restrain Aurora-A kinase activity in vitro, providing further therapeutic avenues to explore." @default.
• W1983973807 created "2016-06-24" @default.
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• W1983973807 date "2006-06-19" @default.
• W1983973807 modified "2023-09-30" @default.
• W1983973807 title "Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies" @default.
• W1983973807 cites W1002836587 @default.
• W1983973807 cites W1568426705 @default.
• W1983973807 cites W1657157395 @default.
• W1983973807 cites W1765359824 @default.
• W1983973807 cites W181176105 @default.
• W1983973807 cites W1886278373 @default.
• W1983973807 cites W1931117085 @default.
• W1983973807 cites W1964253746 @default.
• W1983973807 cites W1965669510 @default.
• W1983973807 cites W1966951204 @default.
• W1983973807 cites W1980577287 @default.
• W1983973807 cites W1981073960 @default.
• W1983973807 cites W1981126536 @default.
• W1983973807 cites W1985501548 @default.
• W1983973807 cites W1986157458 @default.
• W1983973807 cites W1989394815 @default.
• W1983973807 cites W1989524887 @default.
• W1983973807 cites W1990317973 @default.
• W1983973807 cites W1992988824 @default.
• W1983973807 cites W1997678453 @default.
• W1983973807 cites W1998544890 @default.
• W1983973807 cites W2002125670 @default.
• W1983973807 cites W2005355917 @default.
• W1983973807 cites W2006113261 @default.
• W1983973807 cites W2006240263 @default.
• W1983973807 cites W2006811655 @default.
• W1983973807 cites W2009512217 @default.
• W1983973807 cites W2013928497 @default.
• W1983973807 cites W2014473441 @default.
• W1983973807 cites W2015500590 @default.
• W1983973807 cites W2016462887 @default.
• W1983973807 cites W2035845541 @default.
• W1983973807 cites W2046083187 @default.
• W1983973807 cites W2048734578 @default.
• W1983973807 cites W2049838249 @default.
• W1983973807 cites W2051223699 @default.
• W1983973807 cites W2051603299 @default.
• W1983973807 cites W2051717153 @default.
• W1983973807 cites W2052764579 @default.
• W1983973807 cites W2057069307 @default.
• W1983973807 cites W2058245465 @default.
• W1983973807 cites W2060458509 @default.
• W1983973807 cites W2069910776 @default.
• W1983973807 cites W2071156666 @default.
• W1983973807 cites W2079788104 @default.
• W1983973807 cites W2084264782 @default.
• W1983973807 cites W2088309079 @default.
• W1983973807 cites W2089596886 @default.
• W1983973807 cites W2091312754 @default.
• W1983973807 cites W2091455173 @default.
• W1983973807 cites W2092722764 @default.
• W1983973807 cites W2093043664 @default.
• W1983973807 cites W2100521311 @default.
• W1983973807 cites W2106942695 @default.
• W1983973807 cites W2109519875 @default.
• W1983973807 cites W2110944043 @default.
• W1983973807 cites W2112064734 @default.
• W1983973807 cites W2117903145 @default.
• W1983973807 cites W2118460316 @default.
• W1983973807 cites W2125754609 @default.
• W1983973807 cites W2128553601 @default.
• W1983973807 cites W2137429755 @default.
• W1983973807 cites W2138180163 @default.
• W1983973807 cites W2140557275 @default.
• W1983973807 cites W2141627232 @default.
• W1983973807 cites W2141793615 @default.
• W1983973807 cites W2145807414 @default.
• W1983973807 cites W214799791 @default.
• W1983973807 cites W2148649353 @default.
• W1983973807 cites W2149468546 @default.
• W1983973807 cites W2155660862 @default.
• W1983973807 cites W2158171067 @default.
• W1983973807 cites W2166470703 @default.
• W1983973807 cites W2167382061 @default.
• W1983973807 cites W2169220662 @default.
• W1983973807 cites W2189301054 @default.
• W1983973807 cites W2322595909 @default.
• W1983973807 cites W2326161572 @default.
• W1983973807 cites W4251055596 @default.
• W1983973807 doi "https://doi.org/10.1038/sj.onc.1209754" @default.
• W1983973807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16785988" @default.
• W1983973807 hasPublicationYear "2006" @default.
• W1983973807 type Work @default.

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