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• W1983974271 abstract "NGF and IL-3 play a unique role in supporting human basophil differentiation and mediator secretion. Their importance in allergic disease is underlined further by studies showing elevated levels of these factors in asthmatics. Here, we compared the abilities of IL-3 and NGF to stimulate basophil histamine, IL-4 or IL-13 release, either directly or in conjunction with IgE-dependent stimulation and assessed the intracellular signals responsible. Our results show that the ability of IL-3 and NGF to enhance IgE-dependent histamine release are similar. Both factors also potentiated IgE-dependent IL-13 secretion to a greater degree than the release of histamine or IL-4. At high concentrations (100 ng/ml), IL-3 and NGF alone were capable of releasing cytokines but little histamine. These abilities of IL-3 and NGF to modulate basophil activation were sensitive to blockade by specific inhibitors of PI 3-kinase, p38 MAPK and PLC, but not PKC, suggesting that their effects are mediated considerably by pathways comparable to IgE-dependent signalling." @default.
• W1983974271 created "2016-06-24" @default.
• W1983974271 creator A5066661624 @default.
• W1983974271 creator A5078531159 @default.
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• W1983974271 date "2005-04-01" @default.
• W1983974271 modified "2023-10-04" @default.
• W1983974271 title "Nerve growth factor influences IgE-mediated human basophil activation: functional properties and intracellular mechanisms compared with IL-3" @default.
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• W1983974271 doi "https://doi.org/10.1016/j.intimp.2004.12.004" @default.
• W1983974271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15710342" @default.
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