FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983980957> ?p ?o ?g. }

• W1983980957 endingPage "170" @default.
• W1983980957 startingPage "165" @default.
• W1983980957 abstract "CpG-oligodeoxyribonucleotides (CpG-ODNs), which induce signaling through the toll-like receptor 9, are currently under investigation as immunity stimulators against cancer. It has recently been suggested that CpG-ODNs may also enhance sensitivity to traditional therapies including chemotherapy in certain cancer-cell lines. The purpose of this study was to define the activity of CpG-ODN7909 in increasing radiosensitivity of the human non-small cell lung cancer cell line A549 in vitro. First, a dose- and time-dependent inhibitory effect on cell viability was observed after A549 cells were treated with different concentrations of CpG-ODN7909 (5, 10, 30, and 60 microg/mL). Second, decreased cell clonogenic survival, enhanced cell apoptotic index, accumulated percentage of cells in the G2/M phase, and increased tumor necrosis factor (TNF)-alpha secretion were found after combined treatments with 10 microg/mL of CpG-ODN7909 and radiation compared to either treatment alone (p < 0.05). Furthermore, the toll-like receptor 9 mRNA was found to express in A549. The results suggest that CpG-ODN7909 can increase the radiosensitivity of human non-small cell lung cancer A549 cells, which may be associated with reduced cell clonogenic survival, enhanced apoptosis, prolonged cell-cycle arrest in G2/M, and stimulation of TNF-alpha secretion." @default.
• W1983980957 created "2016-06-24" @default.
• W1983980957 creator A5009000813 @default.
• W1983980957 creator A5039724573 @default.
• W1983980957 creator A5058775119 @default.
• W1983980957 creator A5081368889 @default.
• W1983980957 date "2010-04-01" @default.
• W1983980957 modified "2023-10-16" @default.
• W1983980957 title "Enhancement of Radiosensitivity by CpG-Oligodeoxyribonucleotide-7909 in Human Non–Small Cell Lung Cancer A549 Cells" @default.
• W1983980957 cites W1964792110 @default.
• W1983980957 cites W1965293768 @default.
• W1983980957 cites W1973488341 @default.
• W1983980957 cites W1991636753 @default.
• W1983980957 cites W2000213276 @default.
• W1983980957 cites W2005768436 @default.
• W1983980957 cites W2032007643 @default.
• W1983980957 cites W2032783993 @default.
• W1983980957 cites W2037978850 @default.
• W1983980957 cites W2038364908 @default.
• W1983980957 cites W2039461003 @default.
• W1983980957 cites W2044423309 @default.
• W1983980957 cites W2065107255 @default.
• W1983980957 cites W2072239295 @default.
• W1983980957 cites W2083036309 @default.
• W1983980957 cites W2089808194 @default.
• W1983980957 cites W2100544835 @default.
• W1983980957 cites W2117684163 @default.
• W1983980957 cites W2118011548 @default.
• W1983980957 cites W2118015703 @default.
• W1983980957 cites W2128940859 @default.
• W1983980957 cites W2132078058 @default.
• W1983980957 cites W2146593422 @default.
• W1983980957 cites W2154745425 @default.
• W1983980957 cites W2165181124 @default.
• W1983980957 doi "https://doi.org/10.1089/cbr.2009.0686" @default.
• W1983980957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20423229" @default.
• W1983980957 hasPublicationYear "2010" @default.
• W1983980957 type Work @default.
• W1983980957 sameAs 1983980957 @default.
• W1983980957 citedByCount "19" @default.
• W1983980957 countsByYear W19839809572012 @default.
• W1983980957 countsByYear W19839809572013 @default.
• W1983980957 countsByYear W19839809572014 @default.
• W1983980957 countsByYear W19839809572015 @default.
• W1983980957 countsByYear W19839809572016 @default.
• W1983980957 countsByYear W19839809572017 @default.
• W1983980957 countsByYear W19839809572018 @default.
• W1983980957 countsByYear W19839809572020 @default.
• W1983980957 countsByYear W19839809572021 @default.
• W1983980957 crossrefType "journal-article" @default.
• W1983980957 hasAuthorship W1983980957A5009000813 @default.
• W1983980957 hasAuthorship W1983980957A5039724573 @default.
• W1983980957 hasAuthorship W1983980957A5058775119 @default.
• W1983980957 hasAuthorship W1983980957A5081368889 @default.
• W1983980957 hasConcept C117262875 @default.
• W1983980957 hasConcept C121608353 @default.
• W1983980957 hasConcept C126322002 @default.
• W1983980957 hasConcept C190283241 @default.
• W1983980957 hasConcept C203014093 @default.
• W1983980957 hasConcept C206684579 @default.
• W1983980957 hasConcept C2776256026 @default.
• W1983980957 hasConcept C29537977 @default.
• W1983980957 hasConcept C502942594 @default.
• W1983980957 hasConcept C509974204 @default.
• W1983980957 hasConcept C55493867 @default.
• W1983980957 hasConcept C71924100 @default.
• W1983980957 hasConcept C81729549 @default.
• W1983980957 hasConcept C86803240 @default.
• W1983980957 hasConcept C96232424 @default.
• W1983980957 hasConceptScore W1983980957C117262875 @default.
• W1983980957 hasConceptScore W1983980957C121608353 @default.
• W1983980957 hasConceptScore W1983980957C126322002 @default.
• W1983980957 hasConceptScore W1983980957C190283241 @default.
• W1983980957 hasConceptScore W1983980957C203014093 @default.
• W1983980957 hasConceptScore W1983980957C206684579 @default.
• W1983980957 hasConceptScore W1983980957C2776256026 @default.
• W1983980957 hasConceptScore W1983980957C29537977 @default.
• W1983980957 hasConceptScore W1983980957C502942594 @default.
• W1983980957 hasConceptScore W1983980957C509974204 @default.
• W1983980957 hasConceptScore W1983980957C55493867 @default.
• W1983980957 hasConceptScore W1983980957C71924100 @default.
• W1983980957 hasConceptScore W1983980957C81729549 @default.
• W1983980957 hasConceptScore W1983980957C86803240 @default.
• W1983980957 hasConceptScore W1983980957C96232424 @default.
• W1983980957 hasIssue "2" @default.
• W1983980957 hasLocation W19839809571 @default.
• W1983980957 hasLocation W19839809572 @default.
• W1983980957 hasOpenAccess W1983980957 @default.
• W1983980957 hasPrimaryLocation W19839809571 @default.
• W1983980957 hasRelatedWork W1991796693 @default.
• W1983980957 hasRelatedWork W2019133865 @default.
• W1983980957 hasRelatedWork W2119839400 @default.
• W1983980957 hasRelatedWork W2153893305 @default.
• W1983980957 hasRelatedWork W2341629494 @default.
• W1983980957 hasRelatedWork W2887637160 @default.
• W1983980957 hasRelatedWork W3032241117 @default.
• W1983980957 hasRelatedWork W3045868324 @default.
• W1983980957 hasRelatedWork W3087209649 @default.

• next