FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983989966> ?p ?o ?g. }

• W1983989966 endingPage "3057" @default.
• W1983989966 startingPage "3050" @default.
• W1983989966 abstract "Abstract Purpose: The mitogen-activated protein (MAP) kinase pathway is important for cell proliferation, survival, and differentiation, and is frequently up-regulated in cancers. The MAP kinase pathway is also activated after exposure to ionizing radiation. We investigated the effects of AZD6244 (ARRY-142886), an inhibitor of MAP kinase/extracellular signal-regulated kinase 1/2, on radiation response. Experimental Design: The effects of AZD6244 on the in vitro radiosensitivity of human cancer cell lines (A549, MiaPaCa2, and DU145) were evaluated using clonogenic assays. DNA damage repair was evaluated using γH2AX, and mitotic catastrophe was measured using nuclear fragmentation. Cell cycle effects were measured with flow cytometry. Growth delay was used to evaluate the effects of AZD6244 on in vivo tumor radiosensitivity. Results: Exposure of each cell line to AZD6244 before irradiation resulted in an increase in radiosensitivity with dose enhancement factors at a surviving fraction of 0.1, ranging from 1.16 to 2.0. No effects of AZD6244 on radiation-induced apoptosis or persistence of γH2AX foci after irradiation were detected. Cells treated with AZD6244 had an increased mitotic index and decreased Chk1 phosphorylation at 1 and 2 hours after irradiation. Mitotic catastrophe was increased in cells receiving AZD6244 and irradiation compared with the single treatments. In vivo studies revealed that AZD6244 administration to mice bearing A549 tumor xenografts resulted in a greater than additive increase in radiation-induced tumor growth delay (dose enhancement factor of 3.38). Conclusions: These results indicate that AZD6244 can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect involves an increase in mitotic catastrophe." @default.
• W1983989966 created "2016-06-24" @default.
• W1983989966 creator A5006662667 @default.
• W1983989966 creator A5013664293 @default.
• W1983989966 creator A5025833425 @default.
• W1983989966 creator A5031125070 @default.
• W1983989966 creator A5036663495 @default.
• W1983989966 creator A5047853299 @default.
• W1983989966 creator A5074388510 @default.
• W1983989966 creator A5076213753 @default.
• W1983989966 date "2009-04-30" @default.
• W1983989966 modified "2023-10-11" @default.
• W1983989966 title "<i>In vitro</i> and <i>In vivo</i> Radiosensitization with AZD6244 (ARRY-142886), an Inhibitor of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase 1/2 Kinase" @default.
• W1983989966 cites W1971869045 @default.
• W1983989966 cites W1985775217 @default.
• W1983989966 cites W2015296811 @default.
• W1983989966 cites W2017229935 @default.
• W1983989966 cites W2019142280 @default.
• W1983989966 cites W2037574296 @default.
• W1983989966 cites W2039424517 @default.
• W1983989966 cites W2052214059 @default.
• W1983989966 cites W2055288483 @default.
• W1983989966 cites W2056898980 @default.
• W1983989966 cites W2063960509 @default.
• W1983989966 cites W2073165102 @default.
• W1983989966 cites W2081969062 @default.
• W1983989966 cites W2085821905 @default.
• W1983989966 cites W2097735262 @default.
• W1983989966 cites W2109252212 @default.
• W1983989966 cites W2119999819 @default.
• W1983989966 cites W2122992238 @default.
• W1983989966 cites W2129400742 @default.
• W1983989966 cites W2133318290 @default.
• W1983989966 cites W2136745780 @default.
• W1983989966 cites W2138509357 @default.
• W1983989966 cites W2143715819 @default.
• W1983989966 cites W2157016650 @default.
• W1983989966 cites W2159353995 @default.
• W1983989966 cites W2162147795 @default.
• W1983989966 cites W2246856492 @default.
• W1983989966 cites W2301163078 @default.
• W1983989966 cites W2316582027 @default.
• W1983989966 doi "https://doi.org/10.1158/1078-0432.ccr-08-2954" @default.
• W1983989966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2798161" @default.
• W1983989966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19366835" @default.
• W1983989966 hasPublicationYear "2009" @default.
• W1983989966 type Work @default.
• W1983989966 sameAs 1983989966 @default.
• W1983989966 citedByCount "82" @default.
• W1983989966 countsByYear W19839899662012 @default.
• W1983989966 countsByYear W19839899662013 @default.
• W1983989966 countsByYear W19839899662014 @default.
• W1983989966 countsByYear W19839899662015 @default.
• W1983989966 countsByYear W19839899662016 @default.
• W1983989966 countsByYear W19839899662017 @default.
• W1983989966 countsByYear W19839899662018 @default.
• W1983989966 countsByYear W19839899662019 @default.
• W1983989966 countsByYear W19839899662020 @default.
• W1983989966 countsByYear W19839899662021 @default.
• W1983989966 countsByYear W19839899662022 @default.
• W1983989966 countsByYear W19839899662023 @default.
• W1983989966 crossrefType "journal-article" @default.
• W1983989966 hasAuthorship W1983989966A5006662667 @default.
• W1983989966 hasAuthorship W1983989966A5013664293 @default.
• W1983989966 hasAuthorship W1983989966A5025833425 @default.
• W1983989966 hasAuthorship W1983989966A5031125070 @default.
• W1983989966 hasAuthorship W1983989966A5036663495 @default.
• W1983989966 hasAuthorship W1983989966A5047853299 @default.
• W1983989966 hasAuthorship W1983989966A5074388510 @default.
• W1983989966 hasAuthorship W1983989966A5076213753 @default.
• W1983989966 hasBestOaLocation W19839899661 @default.
• W1983989966 hasConcept C126322002 @default.
• W1983989966 hasConcept C153911025 @default.
• W1983989966 hasConcept C184235292 @default.
• W1983989966 hasConcept C186000732 @default.
• W1983989966 hasConcept C190283241 @default.
• W1983989966 hasConcept C206684579 @default.
• W1983989966 hasConcept C29537977 @default.
• W1983989966 hasConcept C502942594 @default.
• W1983989966 hasConcept C509974204 @default.
• W1983989966 hasConcept C55493867 @default.
• W1983989966 hasConcept C71924100 @default.
• W1983989966 hasConcept C86803240 @default.
• W1983989966 hasConcept C95444343 @default.
• W1983989966 hasConcept C97029542 @default.
• W1983989966 hasConceptScore W1983989966C126322002 @default.
• W1983989966 hasConceptScore W1983989966C153911025 @default.
• W1983989966 hasConceptScore W1983989966C184235292 @default.
• W1983989966 hasConceptScore W1983989966C186000732 @default.
• W1983989966 hasConceptScore W1983989966C190283241 @default.
• W1983989966 hasConceptScore W1983989966C206684579 @default.
• W1983989966 hasConceptScore W1983989966C29537977 @default.
• W1983989966 hasConceptScore W1983989966C502942594 @default.
• W1983989966 hasConceptScore W1983989966C509974204 @default.
• W1983989966 hasConceptScore W1983989966C55493867 @default.
• W1983989966 hasConceptScore W1983989966C71924100 @default.
• W1983989966 hasConceptScore W1983989966C86803240 @default.
• W1983989966 hasConceptScore W1983989966C95444343 @default.

• next