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- W1983996935 abstract "Natural killer (NK) cells possess potent cytolytic activity and secrete immune modulating cytokines. The large repertoire of NK cell receptors provides versatility for the identification of infected and transformed cells and for their elimination by NK cells. NK cell responses also stimulate and regulate the adaptive arm of the immune system. We review current knowledge about the molecular specificity of NK cell receptors and about the regulation of NK cell effector functions upon encounter with target cells. Mechanisms of recognition, interplay among receptors, signal integration, and the dynamic fine-tuning of NK cell responses are discussed. New insights into the molecular checkpoints for NK cell effector function are highlighted, and underlying reasons for the complexity in NK cell recognition and signaling are proposed." @default.
- W1983996935 created "2016-06-24" @default.
- W1983996935 creator A5015561854 @default.
- W1983996935 creator A5087340494 @default.
- W1983996935 date "2008-06-01" @default.
- W1983996935 modified "2023-10-10" @default.
- W1983996935 title "Line of attack: NK cell specificity and integration of signals" @default.
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- W1983996935 doi "https://doi.org/10.1016/j.coi.2008.03.005" @default.
- W1983996935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2564616" @default.
- W1983996935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18439809" @default.
- W1983996935 hasPublicationYear "2008" @default.
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