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- W1984002017 abstract "A facile and efficient strategy to prepare drug derivatives with saccharides was developed, and 12 drug–saccharide conjugates were obtained by selective enzymatic synthesis methods. When the transesterification of chlorphenesin vinyl esters with glucose was chosen as a model reaction, the influence of reaction conditions was optimized. Then, we successfully prepared a series of chlorphenesin–saccharide derivatives of three monosaccharides (glucose, mannose and galactose) and three disaccharides (maltose, lactose and sucrose). In order to study the relationship between the solubility of drug–saccharide conjugates and the structure of parent drugs, five hydrophobic drugs (chlorphenesin, mephenesin, guaifenesin, propranolol and clorprenaline) were chosen as substrates to synthesize drug–saccharide conjugates. The results indicated that the aqueous solublity of drug–saccharide derivatives was greatly improved, which was changed by different saccharides and the structure of parent drugs." @default.
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- W1984002017 date "2007-11-01" @default.
- W1984002017 modified "2023-10-18" @default.
- W1984002017 title "Synthesis and characterization of drug–saccharide conjugates by enzymatic strategy in organic media" @default.
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- W1984002017 doi "https://doi.org/10.1016/j.enzmictec.2007.06.009" @default.
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