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- W1984005448 abstract "Pulse pressure is a marker of vascular aging associated with increased risk of cognitive decline. We recently reported an association between pulse pressure and cerebral spinal fluid (CSF)-based biomarkers of Alzheimer's disease (AD). The present study aimed to extend these findings to a much larger sample, the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, and to investigate the modifying role of the apolipoprotein E4 (APOE4) carrier status and age. The study included 661 non-demented participants (ADNI1 = 313; ADNI-GO = 116; ADNI2 = 245) who underwent lumbar puncture for CSF biomarker assessment. Biomarkers included tau, phosphorylated tau (P-tau181), amyloid beta (Aβ1-42), and their ratios (tau:Aβ1-42 and P-tau:Aβ1-42). Multiple linear regression and ANCOVA analyses were used to investigate the relationship between brachial artery pulse pressure (systolic - diastolic pressure) and AD biomarkers, as well as an interaction with APOE4 carrier status (one or more versus no copies of the Ɛ4 allele) and age (quartiles). All analyses controlled for age and gender. There was a significant interaction between pulse pressure and APOE4 carrier status, predicting tau:Aβ1-42 ratio, p = .04, and a trend for Aβ, ΔR2 = .004, β = .31, p = .076. Secondary analyses stratified by APOE4 carrier status indicated that among APOE4 non-carriers, elevated pulse pressure was significantly associated with tau, ΔR2 = .02, β = .14, p = .005, tau:Aβ1-42 ratio, ΔR2 = .02, β = .15, p = .003, and P-tau:Aβ ratio, ΔR2 = .009, β = .10, p = .05. No significant associations were found among APOE4 carriers. Age interactions indicated that the relationship between pulse pressure and all biomarkers was significant among very-old ( ≥80 years) APOE4 non-carriers. In this group, pulse pressure accounted for 7.5-14% of the variance in biomarkers, and biomarker positive individuals exhibited pulse pressure values 5-10mmHg higher than biomarker negative individuals (all p's < .05). Increased pulse pressure is associated with CSF-based AD biomarkers. Findings support the hypothesis that vascular aging may interact with AD pathophysiology at an early stage, and further suggest that this mechanism may be most salient in individuals with fewer genetic determinants and more advanced age." @default.
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- W1984005448 date "2014-07-01" @default.
- W1984005448 modified "2023-09-28" @default.
- W1984005448 title "P2-089: PULSE PRESSURE IS ASSOCIATED WITH AD BIOMARKERS" @default.
- W1984005448 doi "https://doi.org/10.1016/j.jalz.2014.05.763" @default.
- W1984005448 hasPublicationYear "2014" @default.
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