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• W1984006952 abstract "Abstract 1. 1. The alkaline phosphatase activity of the small intestine of the mature mouse is highest at the pyloric end of the duodenum and falls sharply to a much lower level in the jejunum. 2. 2. The high level of activity in the duodenum is accompanied by a high preference for phenylphosphate (PhP) over β-glycerophosphate (bGP). Jejunal and ileal phosphatases show a preference for bGP at maximal activity levels. 3. 3. In the preweaning period alkaline phosphatase activity is uniform throughout the small intestine. All areas hydrolyze bGP more effectively than PhP at this time. 4. 4. The great increase in alkaline phosphatase activity that occurs in the duodenum during the third postnatal week (i.e., just before weaning) involves the appearance of a strong preference for PhP. Further kinetic studies suggest that the preweaning increase in activity in the duodenum represents the synthesis of a new enzyme not previously present in significant quantity. 5. 5. During the third postnatal week jejunal and ileal phosphatase activities rise and fall. The changes are very small in comparison with the large increase occurring concomitantly in the duodenum. 6. 6. In the duodenum, exogenous cortisone brings about the precocious development of large quantities of a phosphatase having a decided preference for PhP. 7. 7. In the jejunum, exogenous cortisone has no influence on phosphatase activity. In the ileum it first depresses, then elevates, phosphatase activity, but the induced alterations do not parallel the normal pattern of change in the preweaning period. 8. 8. Histochemical studies show that the most active phosphatases are localized in the microvilli throughout the intestine. Surface measurements show that differences in activity cannot be attributed to differences in amount of microvilli-bearing surface along the length of the intestine." @default.
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• W1984006952 date "1961-04-01" @default.
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• W1984006952 title "The functional differentiation of the small intestine. VIII. Regional differences in the alkaline phosphatases of the small intestine of the mouse from birth to one year" @default.
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• W1984006952 doi "https://doi.org/10.1016/0012-1606(61)90003-3" @default.
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