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• W1984008456 endingPage "e9326" @default.
• W1984008456 startingPage "e9326" @default.
• W1984008456 abstract "DNA supercoiling plays a major role in many cellular functions. The global DNA conformation is however intimately linked to local DNA-DNA interactions influencing both the physical properties and the biological functions of the supercoiled molecule. Juxtaposition of DNA double helices in ubiquitous crossover arrangements participates in multiple functions such as recombination, gene regulation and DNA packaging. However, little is currently known about how the structure and stability of direct DNA-DNA interactions influence the topological state of DNA. Here, a crystallographic analysis shows that due to the intrinsic helical chirality of DNA, crossovers of opposite handedness exhibit markedly different geometries. While right-handed crossovers are self-fitted by sequence-specific groove-backbone interaction and bridging Mg2+ sites, left-handed crossovers are juxtaposed by groove-groove interaction. Our previous calculations have shown that the different geometries result in differential stabilisation in solution, in the presence of divalent cations. The present study reveals that the various topological states of the cell are associated with different inter-segmental interactions. While the unstable left-handed crossovers are exclusively formed in negatively supercoiled DNA, stable right-handed crossovers constitute the local signature of an unusual topological state in the cell, such as the positively supercoiled or relaxed DNA. These findings not only provide a simple mechanism for locally sensing the DNA topology but also lead to the prediction that, due to their different tertiary intra-molecular interactions, supercoiled molecules of opposite signs must display markedly different physical properties. Sticky inter-segmental interactions in positively supercoiled or relaxed DNA are expected to greatly slow down the slithering dynamics of DNA. We therefore suggest that the intrinsic helical chirality of DNA may have oriented the early evolutionary choices for DNA topology." @default.
• W1984008456 created "2016-06-24" @default.
• W1984008456 creator A5038598216 @default.
• W1984008456 creator A5041782714 @default.
• W1984008456 date "2010-02-19" @default.
• W1984008456 modified "2023-10-02" @default.
• W1984008456 title "Helical Chirality: a Link between Local Interactions and Global Topology in DNA" @default.
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• W1984008456 doi "https://doi.org/10.1371/journal.pone.0009326" @default.
• W1984008456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2824830" @default.
• W1984008456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20174470" @default.
• W1984008456 hasPublicationYear "2010" @default.
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