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• W1984011020 endingPage "4718" @default.
• W1984011020 startingPage "4710" @default.
• W1984011020 abstract "Toll-like receptor 4 (TLR4) mediates brain damage after stroke. Now our objective is to determine TLR4 involvement in stroke-induced neurogenesis. Stroke was induced by permanent middle cerebral artery occlusion in wild-type and TLR4-deficient mice. Stereological and densitometric analysis of immunofluorescence-labeled brain sections and FACS analysis of cell suspensions were performed. Our results show that subventricular zone (SVZ) cell proliferation after stroke depends on infarct size. Second, when comparing brains with similar lesions, TLR4 attenuated SVZ proliferation, as shown by a decrease in prominin-1(+)/EGFR(+)/nestin(-) cells (type-C cells) at 1-2 d, and in BrdU(+) cells at 7 d, in TLR4(+/+) vs. TLR4(-/-) mice. Interestingly, 7 d after the infarct, neuroblasts in TLR4(+/+) mice migrated farther distances, reaching areas closer to the lesion than those in TLR4-deficient mice. However, at 14 d, TLR4-deficient mice presented a higher number of neuroblasts in all migratory zones than the TLR4(+/+) counterparts, which suggests that TLR4 deficiency delays neuroblast migration. Consistently, TLR4(+/+) mice showed an increased number of interneurons (NeuN(+)/BrdU(+)/GAD67(+) cells) in peri-infarct cortex 14-28 d after stroke. Our data indicate that, despite a negative effect on SVZ cell proliferation, TLR4 plays an important role in stroke-induced neurogenesis by promoting neuroblasts migration and increasing the number of new cortical neurons after stroke." @default.
• W1984011020 created "2016-06-24" @default.
• W1984011020 creator A5020184761 @default.
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• W1984011020 date "2014-07-25" @default.
• W1984011020 modified "2023-10-17" @default.
• W1984011020 title "Toll‐like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia" @default.
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• W1984011020 doi "https://doi.org/10.1096/fj.14-252452" @default.
• W1984011020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063846" @default.
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