FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984016988> ?p ?o ?g. }

• W1984016988 endingPage "1337" @default.
• W1984016988 startingPage "1331" @default.
• W1984016988 abstract "Lantana (Lantana camara Linn.) is a noxious weed to which certain medicinal properties have been attributed, but its ingestion has been reported to be highly toxic to animals and humans, especially in the liver. The main hepatotoxin in lantana leaves is believed to be the pentacyclic triterpenoid lantadene A (LA), but the precise mechanism by which it induces hepatotoxicity has not yet been established. This work addressed the action of LA and its reduced derivative (RLA) on mitochondrial bioenergetics. At the concentration range tested (5-25 microM), RLA stimulated state-4 respiration, inhibited state-3 respiration, circumvented oligomycin-inhibited state-3 respiration, dissipated membrane potential and depleted ATP in a concentration-dependent manner. However, LA did not stimulate state-4 respiration, nor did it affect the other mitochondrial parameters to the extent of its reduced derivative. The lantadenes didn't inhibit the CCCP-uncoupled respiration but increased the ATPase activity of intact coupled mitochondria. The ATPase activity of intact uncoupled or disrupted mitochondria was not affected by the compounds. We propose, therefore, that RLA acts as a mitochondrial uncoupler of oxidative phosphorylation, a property that arises from the biotransformation (reduction) of LA, and LA acts in other mitochondrial membrane components rather than the ATP synthase affecting the mitochondrial bioenergetics. Such effects may account for the well-documented hepatoxicity of lantana." @default.
• W1984016988 created "2016-06-24" @default.
• W1984016988 creator A5000205446 @default.
• W1984016988 creator A5006743509 @default.
• W1984016988 creator A5013832408 @default.
• W1984016988 creator A5018372103 @default.
• W1984016988 creator A5027568799 @default.
• W1984016988 creator A5038735934 @default.
• W1984016988 creator A5043504779 @default.
• W1984016988 creator A5045181471 @default.
• W1984016988 creator A5074765371 @default.
• W1984016988 date "2010-06-01" @default.
• W1984016988 modified "2023-10-06" @default.
• W1984016988 title "Comparative effects of lantadene A and its reduced metabolite on mitochondrial bioenergetics" @default.
• W1984016988 cites W1586947032 @default.
• W1984016988 cites W1964126982 @default.
• W1984016988 cites W1978610709 @default.
• W1984016988 cites W1980462764 @default.
• W1984016988 cites W1980556456 @default.
• W1984016988 cites W1995683429 @default.
• W1984016988 cites W2000934753 @default.
• W1984016988 cites W2003141182 @default.
• W1984016988 cites W2003199541 @default.
• W1984016988 cites W2006056566 @default.
• W1984016988 cites W2017138324 @default.
• W1984016988 cites W2024414043 @default.
• W1984016988 cites W2030115186 @default.
• W1984016988 cites W2034011899 @default.
• W1984016988 cites W2039730542 @default.
• W1984016988 cites W2040949231 @default.
• W1984016988 cites W2044959906 @default.
• W1984016988 cites W2046770259 @default.
• W1984016988 cites W2047454146 @default.
• W1984016988 cites W2054518912 @default.
• W1984016988 cites W2056609269 @default.
• W1984016988 cites W2059735700 @default.
• W1984016988 cites W2062232072 @default.
• W1984016988 cites W2064133616 @default.
• W1984016988 cites W2065888021 @default.
• W1984016988 cites W2066519414 @default.
• W1984016988 cites W2089021030 @default.
• W1984016988 cites W2092230232 @default.
• W1984016988 cites W2101893734 @default.
• W1984016988 cites W2109938472 @default.
• W1984016988 cites W2137204069 @default.
• W1984016988 cites W2153435210 @default.
• W1984016988 doi "https://doi.org/10.1016/j.toxicon.2010.02.004" @default.
• W1984016988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20152851" @default.
• W1984016988 hasPublicationYear "2010" @default.
• W1984016988 type Work @default.
• W1984016988 sameAs 1984016988 @default.
• W1984016988 citedByCount "10" @default.
• W1984016988 countsByYear W19840169882012 @default.
• W1984016988 countsByYear W19840169882014 @default.
• W1984016988 countsByYear W19840169882015 @default.
• W1984016988 countsByYear W19840169882020 @default.
• W1984016988 countsByYear W19840169882021 @default.
• W1984016988 countsByYear W19840169882022 @default.
• W1984016988 crossrefType "journal-article" @default.
• W1984016988 hasAuthorship W1984016988A5000205446 @default.
• W1984016988 hasAuthorship W1984016988A5006743509 @default.
• W1984016988 hasAuthorship W1984016988A5013832408 @default.
• W1984016988 hasAuthorship W1984016988A5018372103 @default.
• W1984016988 hasAuthorship W1984016988A5027568799 @default.
• W1984016988 hasAuthorship W1984016988A5038735934 @default.
• W1984016988 hasAuthorship W1984016988A5043504779 @default.
• W1984016988 hasAuthorship W1984016988A5045181471 @default.
• W1984016988 hasAuthorship W1984016988A5074765371 @default.
• W1984016988 hasBestOaLocation W19840169881 @default.
• W1984016988 hasConcept C100206155 @default.
• W1984016988 hasConcept C112243037 @default.
• W1984016988 hasConcept C181199279 @default.
• W1984016988 hasConcept C182215343 @default.
• W1984016988 hasConcept C23265538 @default.
• W1984016988 hasConcept C2779134199 @default.
• W1984016988 hasConcept C2779992206 @default.
• W1984016988 hasConcept C28859421 @default.
• W1984016988 hasConcept C55493867 @default.
• W1984016988 hasConcept C57600042 @default.
• W1984016988 hasConcept C59822182 @default.
• W1984016988 hasConcept C75385678 @default.
• W1984016988 hasConcept C86803240 @default.
• W1984016988 hasConceptScore W1984016988C100206155 @default.
• W1984016988 hasConceptScore W1984016988C112243037 @default.
• W1984016988 hasConceptScore W1984016988C181199279 @default.
• W1984016988 hasConceptScore W1984016988C182215343 @default.
• W1984016988 hasConceptScore W1984016988C23265538 @default.
• W1984016988 hasConceptScore W1984016988C2779134199 @default.
• W1984016988 hasConceptScore W1984016988C2779992206 @default.
• W1984016988 hasConceptScore W1984016988C28859421 @default.
• W1984016988 hasConceptScore W1984016988C55493867 @default.
• W1984016988 hasConceptScore W1984016988C57600042 @default.
• W1984016988 hasConceptScore W1984016988C59822182 @default.
• W1984016988 hasConceptScore W1984016988C75385678 @default.
• W1984016988 hasConceptScore W1984016988C86803240 @default.
• W1984016988 hasIssue "7" @default.
• W1984016988 hasLocation W19840169881 @default.
• W1984016988 hasLocation W19840169882 @default.

• next