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- W1984020440 abstract "This article discusses the role of phosphodiesterase-5 (PDE-5) inhibition in the molecular biology of erectile function and dysfunction. Commercially marketed PDE-5 inhibitors are highly specific for PDE-5, and in the face of continuing cyclic GMP (cGMP) synthesis,elevate cellular cGMP. This elevation results from direct competitive inhibition of PDE-5 and from blocking the negative feedback regulation of the enzyme. Elevation of cGMP activates cGMP-dependent protein kinase, which mediates the effects of the cGMP-signaling pathway to decrease smooth muscle tone and dilate penile vascular smooth muscle. By exploiting features of PDE-5 regulatory mechanisms that modulate PDE-5 function, the inhibitors enhance their own potencies." @default.
- W1984020440 created "2016-06-24" @default.
- W1984020440 creator A5012382947 @default.
- W1984020440 creator A5034675601 @default.
- W1984020440 date "2005-11-01" @default.
- W1984020440 modified "2023-10-14" @default.
- W1984020440 title "Phosphodiesterase-5 Inhibition: the Molecular Biology of Erectile Function and Dysfunction" @default.
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- W1984020440 doi "https://doi.org/10.1016/j.ucl.2005.08.001" @default.
- W1984020440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16291034" @default.
- W1984020440 hasPublicationYear "2005" @default.
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