FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984024359> ?p ?o ?g. }

• W1984024359 endingPage "10647" @default.
• W1984024359 startingPage "10638" @default.
• W1984024359 abstract "PEGylated chlorin e6 photosensitizers were synthesized with tri(ethylene glycol) attached at the ester bond(s) for a 1:1 conjugate at the 173-position, a 2:1 conjugate at the 152- and 173-positions, and a 3:1 conjugate at the 131-, 152-, and 173-positions. These chlorin sensitizers were studied for hydrolytic stability and solubility, as well as ovarian OVCAR-5 cancer cell uptake, localization, and phototoxicity. Increasing numbers of the PEG groups in the mono-, di-, and tri-PEG chlorin conjugates increased the water solubility and sensitivity to hydrolysis and uptake into the ovarian cancer cells. The PEG chlorin conjugates accumulated in the cytoplasm and mitrochondria, but not in lysosomes. Higher phototoxicity was roughly correlated with higher numbers of PEG groups, with the tri-PEG chlorin conjugate showing the best overall ovarian cancer cell photokilling of the series. Singlet oxygen lifetimes, solvent deuteration, and the effects of additives azide ion and d-mannitol were examined to help clarify the photokilling mechanisms. A Type-II (singlet oxygen) photosensitized mechanism is suggested for the di- and tri-PEG chlorin conjugates; however, a more complicated process based in part on a Type-I (radicals or radical ions) mechanism is suggested for the parent chlorin e6 and the mono-PEG chlorin conjugate." @default.
• W1984024359 created "2016-06-24" @default.
• W1984024359 creator A5001405153 @default.
• W1984024359 creator A5004352007 @default.
• W1984024359 creator A5015728263 @default.
• W1984024359 creator A5030881879 @default.
• W1984024359 creator A5051164657 @default.
• W1984024359 creator A5058184923 @default.
• W1984024359 creator A5083623361 @default.
• W1984024359 date "2012-11-14" @default.
• W1984024359 modified "2023-10-18" @default.
• W1984024359 title "Synthesis and Characterization of Mono-, Di-, and Tri-Poly(ethylene glycol) Chlorin e₆ Conjugates for the Photokilling of Human Ovarian Cancer Cells" @default.
• W1984024359 cites W1908936825 @default.
• W1984024359 cites W1980274432 @default.
• W1984024359 cites W1987929665 @default.
• W1984024359 cites W1993735552 @default.
• W1984024359 cites W1999088299 @default.
• W1984024359 cites W2002864487 @default.
• W1984024359 cites W2005482676 @default.
• W1984024359 cites W2016536436 @default.
• W1984024359 cites W2022382669 @default.
• W1984024359 cites W2022976767 @default.
• W1984024359 cites W2028432159 @default.
• W1984024359 cites W2033873138 @default.
• W1984024359 cites W2037772478 @default.
• W1984024359 cites W2044148725 @default.
• W1984024359 cites W2047022945 @default.
• W1984024359 cites W2048292565 @default.
• W1984024359 cites W205414618 @default.
• W1984024359 cites W2055621795 @default.
• W1984024359 cites W2058099666 @default.
• W1984024359 cites W2067452692 @default.
• W1984024359 cites W2072665697 @default.
• W1984024359 cites W2073544629 @default.
• W1984024359 cites W2080742684 @default.
• W1984024359 cites W2082391228 @default.
• W1984024359 cites W2095321104 @default.
• W1984024359 cites W2106952702 @default.
• W1984024359 cites W2107166355 @default.
• W1984024359 cites W2107231628 @default.
• W1984024359 cites W2115356777 @default.
• W1984024359 cites W2163878929 @default.
• W1984024359 cites W2176326379 @default.
• W1984024359 cites W2313119121 @default.
• W1984024359 cites W2333059703 @default.
• W1984024359 cites W2950177539 @default.
• W1984024359 cites W2951678742 @default.
• W1984024359 cites W3004919727 @default.
• W1984024359 cites W3005252895 @default.
• W1984024359 cites W88997352 @default.
• W1984024359 doi "https://doi.org/10.1021/jo301889s" @default.
• W1984024359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3815657" @default.
• W1984024359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23126407" @default.
• W1984024359 hasPublicationYear "2012" @default.
• W1984024359 type Work @default.
• W1984024359 sameAs 1984024359 @default.
• W1984024359 citedByCount "35" @default.
• W1984024359 countsByYear W19840243592013 @default.
• W1984024359 countsByYear W19840243592014 @default.
• W1984024359 countsByYear W19840243592015 @default.
• W1984024359 countsByYear W19840243592016 @default.
• W1984024359 countsByYear W19840243592017 @default.
• W1984024359 countsByYear W19840243592018 @default.
• W1984024359 countsByYear W19840243592019 @default.
• W1984024359 countsByYear W19840243592020 @default.
• W1984024359 countsByYear W19840243592021 @default.
• W1984024359 countsByYear W19840243592022 @default.
• W1984024359 countsByYear W19840243592023 @default.
• W1984024359 crossrefType "journal-article" @default.
• W1984024359 hasAuthorship W1984024359A5001405153 @default.
• W1984024359 hasAuthorship W1984024359A5004352007 @default.
• W1984024359 hasAuthorship W1984024359A5015728263 @default.
• W1984024359 hasAuthorship W1984024359A5030881879 @default.
• W1984024359 hasAuthorship W1984024359A5051164657 @default.
• W1984024359 hasAuthorship W1984024359A5058184923 @default.
• W1984024359 hasAuthorship W1984024359A5083623361 @default.
• W1984024359 hasBestOaLocation W19840243592 @default.
• W1984024359 hasConcept C10138342 @default.
• W1984024359 hasConcept C134306372 @default.
• W1984024359 hasConcept C155574463 @default.
• W1984024359 hasConcept C162324750 @default.
• W1984024359 hasConcept C178790620 @default.
• W1984024359 hasConcept C185592680 @default.
• W1984024359 hasConcept C197336794 @default.
• W1984024359 hasConcept C202751555 @default.
• W1984024359 hasConcept C20639190 @default.
• W1984024359 hasConcept C2777516009 @default.
• W1984024359 hasConcept C2777516457 @default.
• W1984024359 hasConcept C2778178086 @default.
• W1984024359 hasConcept C2781323092 @default.
• W1984024359 hasConcept C33923547 @default.
• W1984024359 hasConcept C540031477 @default.
• W1984024359 hasConcept C54400483 @default.
• W1984024359 hasConcept C55493867 @default.
• W1984024359 hasConcept C75473681 @default.
• W1984024359 hasConceptScore W1984024359C10138342 @default.
• W1984024359 hasConceptScore W1984024359C134306372 @default.
• W1984024359 hasConceptScore W1984024359C155574463 @default.

• next