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• W1984036218 abstract "X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed." @default.
• W1984036218 created "2016-06-24" @default.
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• W1984036218 date "2008-01-18" @default.
• W1984036218 modified "2023-10-05" @default.
• W1984036218 title "Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete" @default.
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• W1984036218 doi "https://doi.org/10.1371/journal.pgen.0040009" @default.
• W1984036218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2213701" @default.
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• W1984036218 hasPublicationYear "2008" @default.
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