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- W1984039400 abstract "The effects of endotoxic shock on the partial reaction of the (Na+ + K+)-ATPase enzyme system, K+-activated para-nitrophenylphosphatase (K+-PNPPase), and on ouabain binding were studied in isolated adult dog heart myocytes. Results obtained 4 hr after endotoxin administration showed that the kinetic parameters of K+-PNPPase such as Vmax and Km for K+ activation, and Vmax, S0.5, and the Hill coefficient for Mg2+ and para-nitrophenylphosphate saturation were not altered. However, the sensitivity of K+-PNPPase to ouabain inhibition was decreased markedly; the I50 value for ouabain inhibition was increased from the control value of 0.39 μM to 2.2 μM in endotoxic shock. Results obtained from ouabain binding studies indicated that the Kd for high-affinity binding was increased by 36% with no change in the Kd for low-affinity binding and no change in the total number of binding sites. The average affinity for ouabain binding at low fractional occupancy of receptor sites was markedly decreased. The effect of ouabain on K+-PNPPase activity was changed from inhibition to activation when less than 32% of the receptor sites were occupied. These data indicate that 4 hr after endotoxin administration, the total number of ouabain receptor sites and the dephosphorylation process of the enzyme cycle were not altered, but the coordination of the ouabain receptor subunit and the catalytic subunit of the enzyme system was impaired. Based on these results, it is concluded that the therapeutic value of cardiac glycosides as a means of improving myocardial contractility during endotoxic shock should be reevaluated." @default.
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- W1984039400 date "1981-09-01" @default.
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- W1984039400 title "Shock-induced changes in the sodiumpotassium adenosine triphosphatase enzyme system in dog hearts" @default.
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- W1984039400 doi "https://doi.org/10.1016/0022-4804(81)90226-2" @default.
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