Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984042891> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1984042891 endingPage "1468" @default.
- W1984042891 startingPage "1465" @default.
- W1984042891 abstract "The GST enzyme, encoded by hGSTA1 gene, catalyses the GSH dependant detoxification of a variety of carcinogenic metabolites and alkylating chemotherapeutic agents. Two genetic variants of hGSTA1, namely hGSTA1*A and hGSTA1*B, are characterized by three linked SNPs, of which −52 G > A variation being solely responsible for the differential promoter activity of hGSTA1. Individuals homozygous for hGSTA1*B have low hepatic expression of hGSTA1. Given the time and labor consuming PCR–RFLP method and the direct prediction of −52 G > A variation, we opted to establish a high throughput DHPLC procedure for the characterization of hGSTA1 variants. 117 DNA samples from South India were included in the study. Control samples were generated for DHPLC using conventional PCR–RFLP technique. Heteroduplexes were produced by in vitro mixing of control DNA samples (hGSTA1*A) to all the samples which are subsequently subjected to DHPLC analysis. The samples were analyzed for the presence of heteroduplexes from the chromatographic profiles. From the total of 117 samples, 43.5% are homozygous for hGSTA1*A allele, 13% are homozygous for hGSTA1*B allele and 43.5% are hGSTA1*A/B heterozygotes. This is, to our knowledge, the first report on the use of DHPLC for the evaluation of hGSTA1 gene promoter polymorphism." @default.
- W1984042891 created "2016-06-24" @default.
- W1984042891 creator A5024742843 @default.
- W1984042891 creator A5030176491 @default.
- W1984042891 creator A5032393853 @default.
- W1984042891 creator A5055508741 @default.
- W1984042891 creator A5062855499 @default.
- W1984042891 creator A5084861477 @default.
- W1984042891 creator A5088411896 @default.
- W1984042891 date "2011-07-01" @default.
- W1984042891 modified "2023-10-18" @default.
- W1984042891 title "Analysis of human glutathione S-transferase alpha 1 (hGSTA1) gene promoter polymorphism using Denaturing High Performance Liquid Chromatography (DHPLC)" @default.
- W1984042891 cites W139901744 @default.
- W1984042891 cites W1902072415 @default.
- W1984042891 cites W1989613812 @default.
- W1984042891 cites W2001587962 @default.
- W1984042891 cites W2050475316 @default.
- W1984042891 cites W2080559885 @default.
- W1984042891 cites W2094776252 @default.
- W1984042891 cites W2100478222 @default.
- W1984042891 cites W2116304499 @default.
- W1984042891 cites W2145688747 @default.
- W1984042891 cites W2157285315 @default.
- W1984042891 doi "https://doi.org/10.1016/j.cca.2011.04.019" @default.
- W1984042891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21530499" @default.
- W1984042891 hasPublicationYear "2011" @default.
- W1984042891 type Work @default.
- W1984042891 sameAs 1984042891 @default.
- W1984042891 citedByCount "5" @default.
- W1984042891 countsByYear W19840428912015 @default.
- W1984042891 countsByYear W19840428912017 @default.
- W1984042891 countsByYear W19840428912018 @default.
- W1984042891 crossrefType "journal-article" @default.
- W1984042891 hasAuthorship W1984042891A5024742843 @default.
- W1984042891 hasAuthorship W1984042891A5030176491 @default.
- W1984042891 hasAuthorship W1984042891A5032393853 @default.
- W1984042891 hasAuthorship W1984042891A5055508741 @default.
- W1984042891 hasAuthorship W1984042891A5062855499 @default.
- W1984042891 hasAuthorship W1984042891A5084861477 @default.
- W1984042891 hasAuthorship W1984042891A5088411896 @default.
- W1984042891 hasConcept C104317684 @default.
- W1984042891 hasConcept C135763542 @default.
- W1984042891 hasConcept C153209595 @default.
- W1984042891 hasConcept C153911025 @default.
- W1984042891 hasConcept C168007829 @default.
- W1984042891 hasConcept C180754005 @default.
- W1984042891 hasConcept C181199279 @default.
- W1984042891 hasConcept C2776053618 @default.
- W1984042891 hasConcept C2776907368 @default.
- W1984042891 hasConcept C49105822 @default.
- W1984042891 hasConcept C538909803 @default.
- W1984042891 hasConcept C54355233 @default.
- W1984042891 hasConcept C55493867 @default.
- W1984042891 hasConcept C86803240 @default.
- W1984042891 hasConceptScore W1984042891C104317684 @default.
- W1984042891 hasConceptScore W1984042891C135763542 @default.
- W1984042891 hasConceptScore W1984042891C153209595 @default.
- W1984042891 hasConceptScore W1984042891C153911025 @default.
- W1984042891 hasConceptScore W1984042891C168007829 @default.
- W1984042891 hasConceptScore W1984042891C180754005 @default.
- W1984042891 hasConceptScore W1984042891C181199279 @default.
- W1984042891 hasConceptScore W1984042891C2776053618 @default.
- W1984042891 hasConceptScore W1984042891C2776907368 @default.
- W1984042891 hasConceptScore W1984042891C49105822 @default.
- W1984042891 hasConceptScore W1984042891C538909803 @default.
- W1984042891 hasConceptScore W1984042891C54355233 @default.
- W1984042891 hasConceptScore W1984042891C55493867 @default.
- W1984042891 hasConceptScore W1984042891C86803240 @default.
- W1984042891 hasFunder F4320320720 @default.
- W1984042891 hasIssue "15-16" @default.
- W1984042891 hasLocation W19840428911 @default.
- W1984042891 hasLocation W19840428912 @default.
- W1984042891 hasOpenAccess W1984042891 @default.
- W1984042891 hasPrimaryLocation W19840428911 @default.
- W1984042891 hasRelatedWork W1135448645 @default.
- W1984042891 hasRelatedWork W1535389135 @default.
- W1984042891 hasRelatedWork W1867987620 @default.
- W1984042891 hasRelatedWork W1967714679 @default.
- W1984042891 hasRelatedWork W1981378087 @default.
- W1984042891 hasRelatedWork W2021855300 @default.
- W1984042891 hasRelatedWork W2054105806 @default.
- W1984042891 hasRelatedWork W2070922469 @default.
- W1984042891 hasRelatedWork W2161808406 @default.
- W1984042891 hasRelatedWork W2223919059 @default.
- W1984042891 hasVolume "412" @default.
- W1984042891 isParatext "false" @default.
- W1984042891 isRetracted "false" @default.
- W1984042891 magId "1984042891" @default.
- W1984042891 workType "article" @default.