FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984052103> ?p ?o ?g. }

• W1984052103 endingPage "1988" @default.
• W1984052103 startingPage "1977" @default.
• W1984052103 abstract "Altered expression of miRNAs contributes to development and progression of non-small cell lung cancer (NSCLC), while transforming growth factor-β (TGF-β) promotes NSCLC cell epithelial-mesenchymal transition. This study aimed to investigate the effects of TGF-β-induced miR‑143 expression in regulation of NSCLC cell viability, invasion capacity in vitro, and xenograft formation and growth in nude mice. NSCLC A549 cells treated with TGF-β were subjected to miRNA microarray analysis and miR‑143 was selected for further study of tumor cell viability, wound healing, invasion capacity in vitro, and tumor growth in nude mice. TGF-β treatment upregulated expression of 16 miRNAs and downregulated expression of 42 miRNAs in A549 cells. qRT-PCR and in situ hybridization data showed that miR‑143 was significantly downregulated in 24 NSCLC and lymph node metastatic tumor tissues, but upregulated by TGF-β treatment in A549 cells. In vitro experiments showed that miR‑143 expression could significantly suppress NSCLC cell viability and invasion capacity, and nude mouse experiments confirmed the in vitro data. Bioinformatic data predicted that Smad3, CD44 and K-Ras were the targeting genes of miR‑143. TGF-β-induced miR‑143 expression was associated with suppressed expression of Smad3, CD44, and K-Ras. This study sheds light on the role of TGF-β in upregulation of miR‑143 and the role of miR‑143 in NSCLC progression, indicating that the target of miR‑143 expression could be further studied as a novel therapeutic strategy for future control of NSCLC." @default.
• W1984052103 created "2016-06-24" @default.
• W1984052103 creator A5009152274 @default.
• W1984052103 creator A5058722612 @default.
• W1984052103 creator A5064022733 @default.
• W1984052103 creator A5067152089 @default.
• W1984052103 creator A5083204917 @default.
• W1984052103 date "2014-08-27" @default.
• W1984052103 modified "2023-09-30" @default.
• W1984052103 title "Transforming growth factor-β-induced miR-143 expression in regulation of non-small cell lung cancer cell viability and invasion capacity in vitro and in vivo" @default.
• W1984052103 cites W1501232718 @default.
• W1984052103 cites W1544520739 @default.
• W1984052103 cites W1979687510 @default.
• W1984052103 cites W1991034124 @default.
• W1984052103 cites W1996445359 @default.
• W1984052103 cites W1997087602 @default.
• W1984052103 cites W1999792045 @default.
• W1984052103 cites W2000768456 @default.
• W1984052103 cites W2002697796 @default.
• W1984052103 cites W2005459775 @default.
• W1984052103 cites W2006112094 @default.
• W1984052103 cites W2006797972 @default.
• W1984052103 cites W2020001721 @default.
• W1984052103 cites W2021560851 @default.
• W1984052103 cites W2021758180 @default.
• W1984052103 cites W2029758324 @default.
• W1984052103 cites W2056424427 @default.
• W1984052103 cites W2058858453 @default.
• W1984052103 cites W2061958868 @default.
• W1984052103 cites W2069465596 @default.
• W1984052103 cites W2075331723 @default.
• W1984052103 cites W2078899050 @default.
• W1984052103 cites W2079189474 @default.
• W1984052103 cites W2094628177 @default.
• W1984052103 cites W2096873453 @default.
• W1984052103 cites W2133409869 @default.
• W1984052103 cites W2137052967 @default.
• W1984052103 cites W2148929244 @default.
• W1984052103 cites W2154761569 @default.
• W1984052103 cites W2162674813 @default.
• W1984052103 cites W2165143391 @default.
• W1984052103 cites W2171296186 @default.
• W1984052103 cites W2316067769 @default.
• W1984052103 doi "https://doi.org/10.3892/ijo.2014.2623" @default.
• W1984052103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25175415" @default.
• W1984052103 hasPublicationYear "2014" @default.
• W1984052103 type Work @default.
• W1984052103 sameAs 1984052103 @default.
• W1984052103 citedByCount "24" @default.
• W1984052103 countsByYear W19840521032015 @default.
• W1984052103 countsByYear W19840521032016 @default.
• W1984052103 countsByYear W19840521032017 @default.
• W1984052103 countsByYear W19840521032018 @default.
• W1984052103 countsByYear W19840521032019 @default.
• W1984052103 countsByYear W19840521032020 @default.
• W1984052103 countsByYear W19840521032021 @default.
• W1984052103 countsByYear W19840521032023 @default.
• W1984052103 crossrefType "journal-article" @default.
• W1984052103 hasAuthorship W1984052103A5009152274 @default.
• W1984052103 hasAuthorship W1984052103A5058722612 @default.
• W1984052103 hasAuthorship W1984052103A5064022733 @default.
• W1984052103 hasAuthorship W1984052103A5067152089 @default.
• W1984052103 hasAuthorship W1984052103A5083204917 @default.
• W1984052103 hasBestOaLocation W19840521031 @default.
• W1984052103 hasConcept C104317684 @default.
• W1984052103 hasConcept C118131993 @default.
• W1984052103 hasConcept C127561419 @default.
• W1984052103 hasConcept C145059251 @default.
• W1984052103 hasConcept C1491633281 @default.
• W1984052103 hasConcept C2780932548 @default.
• W1984052103 hasConcept C2781018059 @default.
• W1984052103 hasConcept C29537977 @default.
• W1984052103 hasConcept C502942594 @default.
• W1984052103 hasConcept C53227056 @default.
• W1984052103 hasConcept C54355233 @default.
• W1984052103 hasConcept C55493867 @default.
• W1984052103 hasConcept C62112901 @default.
• W1984052103 hasConcept C81729549 @default.
• W1984052103 hasConcept C86803240 @default.
• W1984052103 hasConcept C95444343 @default.
• W1984052103 hasConceptScore W1984052103C104317684 @default.
• W1984052103 hasConceptScore W1984052103C118131993 @default.
• W1984052103 hasConceptScore W1984052103C127561419 @default.
• W1984052103 hasConceptScore W1984052103C145059251 @default.
• W1984052103 hasConceptScore W1984052103C1491633281 @default.
• W1984052103 hasConceptScore W1984052103C2780932548 @default.
• W1984052103 hasConceptScore W1984052103C2781018059 @default.
• W1984052103 hasConceptScore W1984052103C29537977 @default.
• W1984052103 hasConceptScore W1984052103C502942594 @default.
• W1984052103 hasConceptScore W1984052103C53227056 @default.
• W1984052103 hasConceptScore W1984052103C54355233 @default.
• W1984052103 hasConceptScore W1984052103C55493867 @default.
• W1984052103 hasConceptScore W1984052103C62112901 @default.
• W1984052103 hasConceptScore W1984052103C81729549 @default.
• W1984052103 hasConceptScore W1984052103C86803240 @default.
• W1984052103 hasConceptScore W1984052103C95444343 @default.
• W1984052103 hasIssue "5" @default.
• W1984052103 hasLocation W19840521031 @default.

• next