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• W1984053204 abstract "Serum C-terminal atrial natriuretic peptide (CT-ANP) and N-terminal pro B-type natriuretic peptide (NT-pro BNP) concentrations have not been measured serially in dogs with chronic pressure overload of the heart.We investigated whether serial evaluation of CT-ANP and NT-pro BNP concentrations is a useful guide to the risk of cardiac remodeling in dogs with a model of aortic stenosis.Six male Beagles.After anesthesia, the aorta was constricted with a polyester band and mean left ventricular systolic pressure (LVPs) was 50 mmHg above baseline. Echocardiographic and intracardiac catheter examinations and blood sampling were performed before surgery and 3 and 6 months after surgery.LVP and left ventricular end-diastolic pressure (LVEDP) were significantly higher at 6 months. Compared with baseline, end-diastolic intraventricular septum thickness (IVSd), left ventricular posterior wall thickness (LVPWd), and relative wall thickness (RWT) were significantly increased 3 and 6 months after aortic constriction. Serum CT-ANP concentrations were increased significantly at 3 months and serum NT-pro BNP concentrations were significantly higher 3 and 6 months after aortic constriction. Serum NT-pro BNP concentration was significantly correlated with LVEDP and IVSd whereas serum CT-ANP concentration was not correlated with any measurement. Stepwise regression analysis showed that LVEDP, IVSd, and RWT could predict serum NT-pro BNP.This study indicated the differential regulation of NT-pro BNP and CT-ANP concentrations during pressure overload. NT-pro BNP assay may be used as an additional screening method to stratify early-stage ventricular remodeling because of aortic constriction." @default.
• W1984053204 created "2016-06-24" @default.
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• W1984053204 date "2008-08-25" @default.
• W1984053204 modified "2023-10-18" @default.
• W1984053204 title "Evaluation of NT-Pro BNP and CT-ANP as Markers of Concentric Hypertrophy in Dogs with a Model of Compensated Aortic Stenosis" @default.
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• W1984053204 doi "https://doi.org/10.1111/j.1939-1676.2008.0161.x" @default.
• W1984053204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18681918" @default.
• W1984053204 hasPublicationYear "2008" @default.
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