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- W1984069892 abstract "In an attempt to combine the HIV-inhibitory capacity of different 2',3'-dideoxynucleoside (ddN) analogs, we have designed and synthesized several dimers of [AZT]-[AZT] and [AZT]-[d4T]. In addition, we also synthesized the dimers of 1-(1H-benzimidazol-1-yl)-1-deoxy-beta-D-ribofuranose. The in vitro anti-HIV activity of these compounds on a pseudotype virus, pNL4-3.Luc.R-E-, in the 293T cells has been determined. Among these compounds, 2,2'-(propane-1,3-diyl)bis[1-(beta-D-ribofuranosyl)-1H-benzimidazole] showed the highest anti-HIV activity with similar effect as AZT." @default.
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- W1984069892 date "2009-12-01" @default.
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- W1984069892 title "Synthesis and Anti-HIV Activity of [ddN]-[ddN] Dimers and Benzimidazole Nucleoside Dimers" @default.
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- W1984069892 doi "https://doi.org/10.1002/cbdv.200800281" @default.
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